Trends and in‐hospital cardiac complications in patients with atrial fibrillation undergoing allogeneic stem cell transplant: A National Inpatient Sample analysis (2002–2019)

Background Cardiovascular comorbidities increase the risk of transplant‐associated complications. However, the impact of atrial fibrillation (AF) as an independent risk factor remains limited. Methods The National Inpatient Sample (NIS) database was queried using the International Classification of Diseases codes to identify patients admitted for allogeneic stem cell transplant (ASCT). The patients were then subclassified into with and without AF. Subsequently, a multivariate logistic regression model was constructed to account for patient demographics, comorbidities, and hospital characteristics to evaluate the impact of AF on the primary outcome of interest: all‐cause mortality, and secondary outcomes of interest that included common hospitalization complications. Results The data for 77 157 cases of ASCT were collected between 2002 and 2019. Among these 5086 (6.6%) cases had concurrent AF. Multivariate logistic regression revealed patients undergoing ASCT with AF had almost a three times higher risk of all‐cause mortality (odds ratio = 2.99 [95% confidence interval: 2.73–3.28]; p