Four New C19‐Diterpenoid Alkaloids from Aconitum nagarum Stapf

Four new aconitine‐type C19‐diterpenoid alkaloids, were isolated from the roots of Aconitum nagarum Stapf which were named as nagarutines A–D (1–4), together with eleven known compounds (5–15). The structures of the compounds were identified by IR, HR‐ESI‐MS, 1D and 2D NMR spectra. All compounds were tested for the inhibitory effect on LPS induced NO production in RAW 264.7 macrophages, compound 7 showed moderate anti‐inflammatory activity effect and Inhibition rate is about 44.50%.