Clinical features and prognosis of juvenile myelomonocytic leukemia: an analysis of 63 cases

To investigate the clinical features of juvenile myelomonocytic leukemia (JMML) and their association with prognosis. Clinical and prognosis data were collected from the children with JMML who were admitted from January 2008 to December 2016, and the influencing factors for prognosis were analyzed. A total of 63 children with JMML were included, with a median age of onset of 25 months and a male/female ratio of 3.2∶1. JMML genetic testing was performed for 54 children, and mutation was the most common mutation and was observed in 23 children (43%), among whom 19 had mutation alone and 4 had compound mutation, followed by mutation observed in 14 children (26%), among whom 12 had mutation alone and 2 had compound mutation. The 5-year overall survival (OS) rate was only 22%±10% in these children with JMML. Of the 63 children, 13 (21%) underwent hematopoietic stem cell transplantation (HSCT). The HSCT group had a significantly higher 5-year OS rate than the non-HSCT group (46%±14% vs 29%±7%,