Clinical benefit and tolerance profile of a keratolytic and hydrating shampoo in subjects with mild to moderate psoriasis. Results from a double‐blind, randomized, vehicle‐controlled study

Introduction Scalp psoriasis frequently goes with other disease location and may lead to a significant burden and impairment of quality of life (QoL). Adherence to local treatments is a frequent problem. A keratolytic and hydrating shampoo containing 2% salicylic acid, 5% urea, and 1% glycerin (active shampoo) has been developed for psoriasis‐prone scalp. Objective To assess the efficacy and tolerability of an active shampoo in subjects with mild to moderate scalp psoriasis. Materials and methods A single‐center, randomized, double‐blind, vehicle‐controlled study was conducted on 67 adults with mild to moderate psoriasis. The active shampoo or its vehicle were applied daily for 14 days and 3 times/week for another 14 days. Assessments included the Psoriasis Scalp Severity Index (PSSI), Investigator Global Assessment (IGA), calculated total surface affected hair, scalp greasiness, irritation, and assessed scalp dermatitis–specific quality‐of‐life issues using SCALPDEX and product acceptability. Results The active shampoo significantly (p