Candidate Angiogenesis‐Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study

Objective Angiogenesis is indeed a vital process in the progression of carcinomas, including that of larynx. Therefore, this study (AngLaC) aimed to identify candidate angiogenesis‐related biomarkers in laryngeal carcinoma patients. Study Design Prospective controlled cohort study. Setting Tertiary referral center. Methods In silico analyses of angiogenesis‐related genes in laryngeal carcinoma were performed to determine candidate biomarkers. Serum levels of candidate biomarkers were determined via enzyme‐linked immunosorbent assay in laryngeal carcinoma patients as well as in an age and gender‐matched control group. The associations of the biomarkers with clinical parameters were investigated. Results The study included 60 laryngeal carcinoma patients and 20 healthy controls. The serum levels of osteopontin, IGFBP‐3, VEGF, sVEGFR‐1, and VEGFR‐2 were significantly higher in the patient group (p