Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus
Purpose Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators...
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| Veröffentlicht in: | Sleep & breathing 2023-10, Vol.27 (5), p.2031-2039 |
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| creator | Rajkov, Branislava Zdravković, Marija Ninić, Ana Brajković, Milica Klašnja, Slobodan Gardijan, Vera Memon, Lidija Munjas, Jelena Mihajlović, Marija Spasojević- Kalimanovska, Vesna Radosavljević, Vojislav Sopić, Miron |
| description | Purpose
Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA.
Methods
Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI |
| doi_str_mv | 10.1007/s11325-023-02809-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2786812470</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2786812470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-f1cf5143b2df04c9b283e07fdde146eeeca64ee339061f08262e11c33418aeaa3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EoqXwAiyQJTZsAh7bNz9LVJUfqRIburYcZ3LrKrGDxynta_GEOPcWkJBgYdma-c6ZkQ9jL0G8BSGadwSg5K4SUpXTiq4Sj9gp7KSsoBHd48NbVN0O5Al7RnQjBOi2g6fsRNUdNFrLU_bjakm4XyebfQw8jnzB5JdrTHbi_RTjwOcYYljdhDZxh9NEPCF5yj7wPQbkeFcciDZ5KRHeYkIee8ppddnfIqcJceF2CWi5DcM_e999vuYu4t3BfM_z_YJc8sHbHjMSn8twn1d6zp6MdiJ88XCfsasPF1_PP1WXXz5-Pn9_WTkl61yN4MYdaNXLYRTadb1sFYpmHAYEXSOis7VGVKoTNYyilbVEAKeUhtaiteqMvTn6Lil-W5GymT1tP2ADxpWMbNq6BakbUdDXf6E3cU2hbGdkW3dNJ7XeKHmkXIpECUezJD_bdG9AmC1Rc0zUlETNIVGziV49WK_9jMNvya8IC6COAJVW2GP6M_s_tj8Bxcmw3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2869792440</pqid></control><display><type>article</type><title>Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus</title><source>SpringerLink Journals</source><creator>Rajkov, Branislava ; Zdravković, Marija ; Ninić, Ana ; Brajković, Milica ; Klašnja, Slobodan ; Gardijan, Vera ; Memon, Lidija ; Munjas, Jelena ; Mihajlović, Marija ; Spasojević- Kalimanovska, Vesna ; Radosavljević, Vojislav ; Sopić, Miron</creator><creatorcontrib>Rajkov, Branislava ; Zdravković, Marija ; Ninić, Ana ; Brajković, Milica ; Klašnja, Slobodan ; Gardijan, Vera ; Memon, Lidija ; Munjas, Jelena ; Mihajlović, Marija ; Spasojević- Kalimanovska, Vesna ; Radosavljević, Vojislav ; Sopić, Miron</creatorcontrib><description>Purpose
Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA.
Methods
Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI < 30: mild to moderate OSA (MM-OSA), AHI ≥ 30: severe OSA (S-OSA). Presence of T2DM was captured: OSA with T2DM (OSA + T2DM), OSA without T2DM (OSA-T2DM). PBMC resistin, CAP1, and CD36 mRNA were determined by real-time PCR.
Results
Resistin mRNA was significantly upregulated in S-OSA (
N
= 54) compared to the MM-OSA (
N
= 52,
P
= 0.043); CAP1 and CD36 mRNA levels did not differ between the groups (
P
= 0.302;
P
= 0.166, respectively). Resistin mRNA was significantly upregulated in OSA + T2DM (
N
= 29) compared to the OSA-T2DM (
N
= 77,
P
= 0.029); CAP1 and CD36 mRNA levels did not differ between the groups (
P
= 0.662;
P
= 0.108, respectively). AHI and T2DM were independent predictors of resistin mRNA above the 75th percentile (OR = 3.717 [1.152–11.991]; OR = 3.261 [1.000–10.630],
P
= 0.042 respectively).
Conclusion
Resistin gene upregulation in S-OSA indicates its possible contribution to increased inflammation in S-OSA and makes it a possible marker of the disease severity. Resistin gene upregulation in OSA + T2DM suggests that a joint effect of these two comorbidities may have a major contribution to increased inflammation and complications that arise from this state.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-023-02809-0</identifier><identifier>PMID: 36917442</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Apnea ; Basic Science • Original Article ; Cardiovascular diseases ; CD36 antigen ; Comorbidity ; Dentistry ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Gene expression ; Inflammation ; Internal Medicine ; Leukocytes (mononuclear) ; Medicine ; Medicine & Public Health ; Neurology ; Otorhinolaryngology ; Pediatrics ; Peripheral blood mononuclear cells ; Pneumology/Respiratory System ; Sleep apnea ; Sleep disorders ; Up-regulation</subject><ispartof>Sleep & breathing, 2023-10, Vol.27 (5), p.2031-2039</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-f1cf5143b2df04c9b283e07fdde146eeeca64ee339061f08262e11c33418aeaa3</cites><orcidid>0000-0002-4576-1722 ; 0000-0003-3838-1606 ; 0000-0003-3283-9487</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-023-02809-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-023-02809-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36917442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajkov, Branislava</creatorcontrib><creatorcontrib>Zdravković, Marija</creatorcontrib><creatorcontrib>Ninić, Ana</creatorcontrib><creatorcontrib>Brajković, Milica</creatorcontrib><creatorcontrib>Klašnja, Slobodan</creatorcontrib><creatorcontrib>Gardijan, Vera</creatorcontrib><creatorcontrib>Memon, Lidija</creatorcontrib><creatorcontrib>Munjas, Jelena</creatorcontrib><creatorcontrib>Mihajlović, Marija</creatorcontrib><creatorcontrib>Spasojević- Kalimanovska, Vesna</creatorcontrib><creatorcontrib>Radosavljević, Vojislav</creatorcontrib><creatorcontrib>Sopić, Miron</creatorcontrib><title>Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Purpose
Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA.
Methods
Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI < 30: mild to moderate OSA (MM-OSA), AHI ≥ 30: severe OSA (S-OSA). Presence of T2DM was captured: OSA with T2DM (OSA + T2DM), OSA without T2DM (OSA-T2DM). PBMC resistin, CAP1, and CD36 mRNA were determined by real-time PCR.
Results
Resistin mRNA was significantly upregulated in S-OSA (
N
= 54) compared to the MM-OSA (
N
= 52,
P
= 0.043); CAP1 and CD36 mRNA levels did not differ between the groups (
P
= 0.302;
P
= 0.166, respectively). Resistin mRNA was significantly upregulated in OSA + T2DM (
N
= 29) compared to the OSA-T2DM (
N
= 77,
P
= 0.029); CAP1 and CD36 mRNA levels did not differ between the groups (
P
= 0.662;
P
= 0.108, respectively). AHI and T2DM were independent predictors of resistin mRNA above the 75th percentile (OR = 3.717 [1.152–11.991]; OR = 3.261 [1.000–10.630],
P
= 0.042 respectively).
Conclusion
Resistin gene upregulation in S-OSA indicates its possible contribution to increased inflammation in S-OSA and makes it a possible marker of the disease severity. Resistin gene upregulation in OSA + T2DM suggests that a joint effect of these two comorbidities may have a major contribution to increased inflammation and complications that arise from this state.</description><subject>Apnea</subject><subject>Basic Science • Original Article</subject><subject>Cardiovascular diseases</subject><subject>CD36 antigen</subject><subject>Comorbidity</subject><subject>Dentistry</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Gene expression</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Leukocytes (mononuclear)</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Peripheral blood mononuclear cells</subject><subject>Pneumology/Respiratory System</subject><subject>Sleep apnea</subject><subject>Sleep disorders</subject><subject>Up-regulation</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQhS0EoqXwAiyQJTZsAh7bNz9LVJUfqRIburYcZ3LrKrGDxynta_GEOPcWkJBgYdma-c6ZkQ9jL0G8BSGadwSg5K4SUpXTiq4Sj9gp7KSsoBHd48NbVN0O5Al7RnQjBOi2g6fsRNUdNFrLU_bjakm4XyebfQw8jnzB5JdrTHbi_RTjwOcYYljdhDZxh9NEPCF5yj7wPQbkeFcciDZ5KRHeYkIee8ppddnfIqcJceF2CWi5DcM_e999vuYu4t3BfM_z_YJc8sHbHjMSn8twn1d6zp6MdiJ88XCfsasPF1_PP1WXXz5-Pn9_WTkl61yN4MYdaNXLYRTadb1sFYpmHAYEXSOis7VGVKoTNYyilbVEAKeUhtaiteqMvTn6Lil-W5GymT1tP2ADxpWMbNq6BakbUdDXf6E3cU2hbGdkW3dNJ7XeKHmkXIpECUezJD_bdG9AmC1Rc0zUlETNIVGziV49WK_9jMNvya8IC6COAJVW2GP6M_s_tj8Bxcmw3g</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Rajkov, Branislava</creator><creator>Zdravković, Marija</creator><creator>Ninić, Ana</creator><creator>Brajković, Milica</creator><creator>Klašnja, Slobodan</creator><creator>Gardijan, Vera</creator><creator>Memon, Lidija</creator><creator>Munjas, Jelena</creator><creator>Mihajlović, Marija</creator><creator>Spasojević- Kalimanovska, Vesna</creator><creator>Radosavljević, Vojislav</creator><creator>Sopić, Miron</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4576-1722</orcidid><orcidid>https://orcid.org/0000-0003-3838-1606</orcidid><orcidid>https://orcid.org/0000-0003-3283-9487</orcidid></search><sort><creationdate>20231001</creationdate><title>Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus</title><author>Rajkov, Branislava ; Zdravković, Marija ; Ninić, Ana ; Brajković, Milica ; Klašnja, Slobodan ; Gardijan, Vera ; Memon, Lidija ; Munjas, Jelena ; Mihajlović, Marija ; Spasojević- Kalimanovska, Vesna ; Radosavljević, Vojislav ; Sopić, Miron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-f1cf5143b2df04c9b283e07fdde146eeeca64ee339061f08262e11c33418aeaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apnea</topic><topic>Basic Science • Original Article</topic><topic>Cardiovascular diseases</topic><topic>CD36 antigen</topic><topic>Comorbidity</topic><topic>Dentistry</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Gene expression</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Leukocytes (mononuclear)</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Peripheral blood mononuclear cells</topic><topic>Pneumology/Respiratory System</topic><topic>Sleep apnea</topic><topic>Sleep disorders</topic><topic>Up-regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajkov, Branislava</creatorcontrib><creatorcontrib>Zdravković, Marija</creatorcontrib><creatorcontrib>Ninić, Ana</creatorcontrib><creatorcontrib>Brajković, Milica</creatorcontrib><creatorcontrib>Klašnja, Slobodan</creatorcontrib><creatorcontrib>Gardijan, Vera</creatorcontrib><creatorcontrib>Memon, Lidija</creatorcontrib><creatorcontrib>Munjas, Jelena</creatorcontrib><creatorcontrib>Mihajlović, Marija</creatorcontrib><creatorcontrib>Spasojević- Kalimanovska, Vesna</creatorcontrib><creatorcontrib>Radosavljević, Vojislav</creatorcontrib><creatorcontrib>Sopić, Miron</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajkov, Branislava</au><au>Zdravković, Marija</au><au>Ninić, Ana</au><au>Brajković, Milica</au><au>Klašnja, Slobodan</au><au>Gardijan, Vera</au><au>Memon, Lidija</au><au>Munjas, Jelena</au><au>Mihajlović, Marija</au><au>Spasojević- Kalimanovska, Vesna</au><au>Radosavljević, Vojislav</au><au>Sopić, Miron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>27</volume><issue>5</issue><spage>2031</spage><epage>2039</epage><pages>2031-2039</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Purpose
Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA.
Methods
Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI < 30: mild to moderate OSA (MM-OSA), AHI ≥ 30: severe OSA (S-OSA). Presence of T2DM was captured: OSA with T2DM (OSA + T2DM), OSA without T2DM (OSA-T2DM). PBMC resistin, CAP1, and CD36 mRNA were determined by real-time PCR.
Results
Resistin mRNA was significantly upregulated in S-OSA (
N
= 54) compared to the MM-OSA (
N
= 52,
P
= 0.043); CAP1 and CD36 mRNA levels did not differ between the groups (
P
= 0.302;
P
= 0.166, respectively). Resistin mRNA was significantly upregulated in OSA + T2DM (
N
= 29) compared to the OSA-T2DM (
N
= 77,
P
= 0.029); CAP1 and CD36 mRNA levels did not differ between the groups (
P
= 0.662;
P
= 0.108, respectively). AHI and T2DM were independent predictors of resistin mRNA above the 75th percentile (OR = 3.717 [1.152–11.991]; OR = 3.261 [1.000–10.630],
P
= 0.042 respectively).
Conclusion
Resistin gene upregulation in S-OSA indicates its possible contribution to increased inflammation in S-OSA and makes it a possible marker of the disease severity. Resistin gene upregulation in OSA + T2DM suggests that a joint effect of these two comorbidities may have a major contribution to increased inflammation and complications that arise from this state.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36917442</pmid><doi>10.1007/s11325-023-02809-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4576-1722</orcidid><orcidid>https://orcid.org/0000-0003-3838-1606</orcidid><orcidid>https://orcid.org/0000-0003-3283-9487</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Sleep & breathing, 2023-10, Vol.27 (5), p.2031-2039 |
| issn | 1520-9512 1522-1709 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2786812470 |
| source | SpringerLink Journals |
| subjects | Apnea Basic Science • Original Article Cardiovascular diseases CD36 antigen Comorbidity Dentistry Diabetes Diabetes mellitus (non-insulin dependent) Gene expression Inflammation Internal Medicine Leukocytes (mononuclear) Medicine Medicine & Public Health Neurology Otorhinolaryngology Pediatrics Peripheral blood mononuclear cells Pneumology/Respiratory System Sleep apnea Sleep disorders Up-regulation |
| title | Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus |
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