Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus

Purpose Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators...

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Veröffentlicht in:	Sleep & breathing 2023-10, Vol.27 (5), p.2031-2039
Hauptverfasser:	Rajkov, Branislava, Zdravković, Marija, Ninić, Ana, Brajković, Milica, Klašnja, Slobodan, Gardijan, Vera, Memon, Lidija, Munjas, Jelena, Mihajlović, Marija, Spasojević- Kalimanovska, Vesna, Radosavljević, Vojislav, Sopić, Miron
Format:	Artikel
Sprache:	eng
Schlagworte:	Apnea Basic Science • Original Article Cardiovascular diseases CD36 antigen Comorbidity Dentistry Diabetes Diabetes mellitus (non-insulin dependent) Gene expression Inflammation Internal Medicine Leukocytes (mononuclear) Medicine Medicine & Public Health Neurology Otorhinolaryngology Pediatrics Peripheral blood mononuclear cells Pneumology/Respiratory System Sleep apnea Sleep disorders Up-regulation
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Zusammenfassung:	Purpose Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA. Methods Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI
ISSN:	1520-9512 1522-1709
DOI:	10.1007/s11325-023-02809-0