Rates and predictors of 30‐day hospital readmissions in adults for drug‐induced acute pancreatitis: A retrospective study from the United States National Readmission Database
Background and Aim Drug‐induced acute pancreatitis (DIAP) linked to several medications is a diagnosis of exclusion and is associated with significant morbidity and mortality, contributing to the US healthcare cost burden. Existing studies on DIAP focus on the drug classes that can cause acute pancr...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2023-08, Vol.38 (8), p.1277-1282 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Ebhohon, Ebehiwele Khoshbin, Katayoun Shaka, Hafeez |
| description | Background and Aim
Drug‐induced acute pancreatitis (DIAP) linked to several medications is a diagnosis of exclusion and is associated with significant morbidity and mortality, contributing to the US healthcare cost burden. Existing studies on DIAP focus on the drug classes that can cause acute pancreatitis. Hence, our retrospective study aims to determine the rates and predictors for 30‐day readmissions (30‐DR) in patients with index hospitalization for DIAP.
Methods
From the Nationwide Readmissions Database, we followed adults admitted for DIAP who were discharged alive for 30 days. During 30‐DR, we evaluated the rates, predictors, and outcomes of DIAP.
Results
Of the 4457 DIAP patients surviving at discharge, 12.5% were readmitted at 30 days. During readmissions, the predictors of 30‐DR for DIAP were young age, the Charlson–Deyo Comorbidity Index of 2 and 3, protein‐energy malnutrition, and dyslipidemia. During 30‐DR, DIAP had a higher mortality rate (2.4% vs. 0.7%; P |
| doi_str_mv | 10.1111/jgh.16177 |
| format | Article |
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Drug‐induced acute pancreatitis (DIAP) linked to several medications is a diagnosis of exclusion and is associated with significant morbidity and mortality, contributing to the US healthcare cost burden. Existing studies on DIAP focus on the drug classes that can cause acute pancreatitis. Hence, our retrospective study aims to determine the rates and predictors for 30‐day readmissions (30‐DR) in patients with index hospitalization for DIAP.
Methods
From the Nationwide Readmissions Database, we followed adults admitted for DIAP who were discharged alive for 30 days. During 30‐DR, we evaluated the rates, predictors, and outcomes of DIAP.
Results
Of the 4457 DIAP patients surviving at discharge, 12.5% were readmitted at 30 days. During readmissions, the predictors of 30‐DR for DIAP were young age, the Charlson–Deyo Comorbidity Index of 2 and 3, protein‐energy malnutrition, and dyslipidemia. During 30‐DR, DIAP had a higher mortality rate (2.4% vs. 0.7%; P < 0.020), extended hospital stays (5.6 days vs. 4 days, 0.000), and higher hospital charges ($12 983.6 vs. $8 255.6; P 0.000).
Conclusions
DIAP has high 30‐DR rates and poorer outcomes.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.16177</identifier><identifier>PMID: 36914611</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Comorbidity ; Dyslipidemia ; Hospital charges ; Length of stay ; Morbidity ; Mortality ; Nationwide readmissions database ; Pancreatitis ; Patients ; Protein-energy malnutrition</subject><ispartof>Journal of gastroenterology and hepatology, 2023-08, Vol.38 (8), p.1277-1282</ispartof><rights>2023 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2023 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-c38e2e1e2ee2979c6e069c528dbbb4a8aae2f00ac8752b962f988856504dc1e93</citedby><cites>FETCH-LOGICAL-c3537-c38e2e1e2ee2979c6e069c528dbbb4a8aae2f00ac8752b962f988856504dc1e93</cites><orcidid>0000-0002-8642-049X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.16177$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.16177$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36914611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ebhohon, Ebehiwele</creatorcontrib><creatorcontrib>Khoshbin, Katayoun</creatorcontrib><creatorcontrib>Shaka, Hafeez</creatorcontrib><title>Rates and predictors of 30‐day hospital readmissions in adults for drug‐induced acute pancreatitis: A retrospective study from the United States National Readmission Database</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Drug‐induced acute pancreatitis (DIAP) linked to several medications is a diagnosis of exclusion and is associated with significant morbidity and mortality, contributing to the US healthcare cost burden. Existing studies on DIAP focus on the drug classes that can cause acute pancreatitis. Hence, our retrospective study aims to determine the rates and predictors for 30‐day readmissions (30‐DR) in patients with index hospitalization for DIAP.
Methods
From the Nationwide Readmissions Database, we followed adults admitted for DIAP who were discharged alive for 30 days. During 30‐DR, we evaluated the rates, predictors, and outcomes of DIAP.
Results
Of the 4457 DIAP patients surviving at discharge, 12.5% were readmitted at 30 days. During readmissions, the predictors of 30‐DR for DIAP were young age, the Charlson–Deyo Comorbidity Index of 2 and 3, protein‐energy malnutrition, and dyslipidemia. During 30‐DR, DIAP had a higher mortality rate (2.4% vs. 0.7%; P < 0.020), extended hospital stays (5.6 days vs. 4 days, 0.000), and higher hospital charges ($12 983.6 vs. $8 255.6; P 0.000).
Conclusions
DIAP has high 30‐DR rates and poorer outcomes.</description><subject>Comorbidity</subject><subject>Dyslipidemia</subject><subject>Hospital charges</subject><subject>Length of stay</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Nationwide readmissions database</subject><subject>Pancreatitis</subject><subject>Patients</subject><subject>Protein-energy malnutrition</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kU1uFDEQhS1ERCaBBRdAltiQxSR2d9tts4sCJEQRSIGsW267OuNRT7vxD2h2HIGzcCROQpEJICFhya7N915V-RHylLNjjudkfbs65pK37QOy4E3Dlrxt5EOyYIqLpa653icHKa0ZYw1rxSOyX0vNG8n5gny_NhkSNZOjcwTnbQ4x0TDQmv34-s2ZLV2FNPtsRhrBuI1PyYcpUT9R48qYEx1CpC6WW8T95IoFR40tGehsJoua7LNPL-kp6nNEL7DZfwaacnFbOsSwoXkF9GbyGZUf8t0471AVJux5_bcnfWWy6U2Cx2RvMGOCJ_f1kNy8ef3x7GJ59f787dnp1dLWom7xVVABxwuVbrWVwKS2olKu7_vGKGOgGhgzVrWi6rWsBq2UElKwxlkOuj4kL3a-cwyfCqTc4SQWxtFMEErqqlZJxVmjGKLP_0HXoURcACkllNBMyRqpox1l8R9ShKGbo9-YuO04634F2WGQ3V2QyD67dyz9Btwf8ndyCJzsgC9-hO3_nbrL84ud5U8fN6xn</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Ebhohon, Ebehiwele</creator><creator>Khoshbin, Katayoun</creator><creator>Shaka, Hafeez</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8642-049X</orcidid></search><sort><creationdate>202308</creationdate><title>Rates and predictors of 30‐day hospital readmissions in adults for drug‐induced acute pancreatitis: A retrospective study from the United States National Readmission Database</title><author>Ebhohon, Ebehiwele ; Khoshbin, Katayoun ; Shaka, Hafeez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-c38e2e1e2ee2979c6e069c528dbbb4a8aae2f00ac8752b962f988856504dc1e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Comorbidity</topic><topic>Dyslipidemia</topic><topic>Hospital charges</topic><topic>Length of stay</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Nationwide readmissions database</topic><topic>Pancreatitis</topic><topic>Patients</topic><topic>Protein-energy malnutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ebhohon, Ebehiwele</creatorcontrib><creatorcontrib>Khoshbin, Katayoun</creatorcontrib><creatorcontrib>Shaka, Hafeez</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ebhohon, Ebehiwele</au><au>Khoshbin, Katayoun</au><au>Shaka, Hafeez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rates and predictors of 30‐day hospital readmissions in adults for drug‐induced acute pancreatitis: A retrospective study from the United States National Readmission Database</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2023-08</date><risdate>2023</risdate><volume>38</volume><issue>8</issue><spage>1277</spage><epage>1282</epage><pages>1277-1282</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Drug‐induced acute pancreatitis (DIAP) linked to several medications is a diagnosis of exclusion and is associated with significant morbidity and mortality, contributing to the US healthcare cost burden. Existing studies on DIAP focus on the drug classes that can cause acute pancreatitis. Hence, our retrospective study aims to determine the rates and predictors for 30‐day readmissions (30‐DR) in patients with index hospitalization for DIAP.
Methods
From the Nationwide Readmissions Database, we followed adults admitted for DIAP who were discharged alive for 30 days. During 30‐DR, we evaluated the rates, predictors, and outcomes of DIAP.
Results
Of the 4457 DIAP patients surviving at discharge, 12.5% were readmitted at 30 days. During readmissions, the predictors of 30‐DR for DIAP were young age, the Charlson–Deyo Comorbidity Index of 2 and 3, protein‐energy malnutrition, and dyslipidemia. During 30‐DR, DIAP had a higher mortality rate (2.4% vs. 0.7%; P < 0.020), extended hospital stays (5.6 days vs. 4 days, 0.000), and higher hospital charges ($12 983.6 vs. $8 255.6; P 0.000).
Conclusions
DIAP has high 30‐DR rates and poorer outcomes.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36914611</pmid><doi>10.1111/jgh.16177</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8642-049X</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Comorbidity Dyslipidemia Hospital charges Length of stay Morbidity Mortality Nationwide readmissions database Pancreatitis Patients Protein-energy malnutrition |
| title | Rates and predictors of 30‐day hospital readmissions in adults for drug‐induced acute pancreatitis: A retrospective study from the United States National Readmission Database |
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