ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

Metastatic cancer cells upregulate ANO1 to activate cell-intrinsic and -extrinsic mechanisms that alter cholesterol metabolism and stimulate fibroblasts, which can be targeted with ANO1 inhibitors to inhibit metastatic growth. See related commentary by Singh and Mehla, p. 1759.

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2023-06, Vol.83 (11), p.1851-1865
Hauptverfasser: Deng, Chun-Miao, Zhang, Guo-Geng, Liu, Qin-Wen, Xu, Jiao-Jiao, Liu, Zhi-Chao, Yang, Jing, Xu, Tao-Yang, Li, Zhi-Gang, Zhang, Fan, Li, Bin
Format: Artikel
Sprache:eng
Schlagworte:
Anoctamin-1 - metabolism
Cell Line, Tumor
Cholesterol - metabolism
Fibroblasts - metabolism
Humans
Neoplasm Proteins - metabolism
Neoplasms - metabolism
Tumor Microenvironment
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Zusammenfassung:Metastatic cancer cells upregulate ANO1 to activate cell-intrinsic and -extrinsic mechanisms that alter cholesterol metabolism and stimulate fibroblasts, which can be targeted with ANO1 inhibitors to inhibit metastatic growth. See related commentary by Singh and Mehla, p. 1759.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-22-3490