Periodontitis deteriorates renal fibrosis and macrophage infiltration in rats with chronic kidney disease
Objective The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy (Nx)‐induced chronic kidney disease (CKD). Methods Rats were divided into sham surgery (Sham), Sham with tooth ligation (ShamL), Nx, and NxL groups. P...
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| Veröffentlicht in: | Oral diseases 2024-04, Vol.30 (3), p.1497-1505 |
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| creator | Lee, Youn Soo Kim, Ae Ri Jeon, Yeong‐Eui Bak, Eun‐Jung Yoo, Yun‐Jung |
| description | Objective
The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy (Nx)‐induced chronic kidney disease (CKD).
Methods
Rats were divided into sham surgery (Sham), Sham with tooth ligation (ShamL), Nx, and NxL groups. Periodontitis was induced by tooth ligation at 16‐week olds. Creatinine, alveolar bone area, and renal histopathology were analyzed at 20‐week olds.
Results
Creatinine did not differ between the Sham and ShamL groups or between the Nx and NxL groups. The ShamL and NxL groups (both p = 0.002) had less alveolar bone area than the Sham group. The NxL group had fewer glomeruli than the Nx group (p |
| doi_str_mv | 10.1111/odi.14561 |
| format | Article |
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The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy (Nx)‐induced chronic kidney disease (CKD).
Methods
Rats were divided into sham surgery (Sham), Sham with tooth ligation (ShamL), Nx, and NxL groups. Periodontitis was induced by tooth ligation at 16‐week olds. Creatinine, alveolar bone area, and renal histopathology were analyzed at 20‐week olds.
Results
Creatinine did not differ between the Sham and ShamL groups or between the Nx and NxL groups. The ShamL and NxL groups (both p = 0.002) had less alveolar bone area than the Sham group. The NxL group had fewer glomeruli than the Nx group (p < 0.000). The periodontitis groups demonstrated more tubulointerstitial fibrosis (Sham vs. ShamL p = 0.002, Nx vs. NxL p < 0.000) and macrophage infiltration (Sham vs. ShamL p = 0.002, Nx vs. NxL p = 0.006) than the groups without periodontitis. Only the NxL group had greater renal TNFα expression than the Sham group (p < 0.003).
Conclusions
These suggest that periodontitis increases renal fibrosis and inflammation in the presence or absence of CKD but does not affect renal function. Periodontitis also increases TNFα expression in the presence of CKD.</description><identifier>ISSN: 1354-523X</identifier><identifier>ISSN: 1601-0825</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.14561</identifier><identifier>PMID: 36905098</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Alveolar bone ; Animals ; chronic kidney disease ; Creatinine ; Creatinine - blood ; Fibrosis ; Glomerulus ; Gum disease ; Kidney - pathology ; Kidney diseases ; macrophage ; Macrophages ; Macrophages - pathology ; Male ; Nephrectomy ; Periodontitis ; Periodontitis - complications ; Periodontitis - pathology ; Rats ; Rats, Sprague-Dawley ; Renal function ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - etiology ; Renal Insufficiency, Chronic - pathology ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-α</subject><ispartof>Oral diseases, 2024-04, Vol.30 (3), p.1497-1505</ispartof><rights>2023 Wiley Periodicals LLC.</rights><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3131-92a6b167d9daffed9a3e02445b1981fb8dd0d437de37965a34ef69db9c47eb3d3</cites><orcidid>0000-0002-5661-9596 ; 0000-0002-7976-8594 ; 0000-0002-0045-9597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.14561$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.14561$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36905098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Youn Soo</creatorcontrib><creatorcontrib>Kim, Ae Ri</creatorcontrib><creatorcontrib>Jeon, Yeong‐Eui</creatorcontrib><creatorcontrib>Bak, Eun‐Jung</creatorcontrib><creatorcontrib>Yoo, Yun‐Jung</creatorcontrib><title>Periodontitis deteriorates renal fibrosis and macrophage infiltration in rats with chronic kidney disease</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy (Nx)‐induced chronic kidney disease (CKD).
Methods
Rats were divided into sham surgery (Sham), Sham with tooth ligation (ShamL), Nx, and NxL groups. Periodontitis was induced by tooth ligation at 16‐week olds. Creatinine, alveolar bone area, and renal histopathology were analyzed at 20‐week olds.
Results
Creatinine did not differ between the Sham and ShamL groups or between the Nx and NxL groups. The ShamL and NxL groups (both p = 0.002) had less alveolar bone area than the Sham group. The NxL group had fewer glomeruli than the Nx group (p < 0.000). The periodontitis groups demonstrated more tubulointerstitial fibrosis (Sham vs. ShamL p = 0.002, Nx vs. NxL p < 0.000) and macrophage infiltration (Sham vs. ShamL p = 0.002, Nx vs. NxL p = 0.006) than the groups without periodontitis. Only the NxL group had greater renal TNFα expression than the Sham group (p < 0.003).
Conclusions
These suggest that periodontitis increases renal fibrosis and inflammation in the presence or absence of CKD but does not affect renal function. Periodontitis also increases TNFα expression in the presence of CKD.</description><subject>Alveolar bone</subject><subject>Animals</subject><subject>chronic kidney disease</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Fibrosis</subject><subject>Glomerulus</subject><subject>Gum disease</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>macrophage</subject><subject>Macrophages</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Nephrectomy</subject><subject>Periodontitis</subject><subject>Periodontitis - complications</subject><subject>Periodontitis - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renal function</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - etiology</subject><subject>Renal Insufficiency, Chronic - pathology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-α</subject><issn>1354-523X</issn><issn>1601-0825</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAUx4Mobk4P_gMS8KKHbknTtM1R5k8YzIOCt5A2ry6za2bSMvbfm9npQfBd3nu8Dx94X4TOKRnTUBOrzZgmPKUHaEhTQiOSx_wwzIwnEY_Z2wCdeL8khGaCxcdowFJBOBH5EJlncMZq27SmNR5raHe7Uy147KBRNa5M4awPN9VovFKls-uFegdsmsrUbSCNbcKCw-TxxrQLXC6cbUyJP4xuYIu18aA8nKKjStUezvZ9hF7v716mj9Fs_vA0vZlFJaOMRiJWaUHTTAutqgq0UAxInCS8oCKnVZFrTXTCMg0sEylXLIEqFboQZZJBwTQboaveu3b2swPfypXxJdS1asB2XsZZnlIShFlAL_-gS9u58LSXjPCEUB7AQF33VHjdeweVXDuzUm4rKZG7_GXIX37nH9iLvbErVqB_yZ_AAzDpgY2pYfu_Sc5vn3rlFx8NkNw</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Lee, Youn Soo</creator><creator>Kim, Ae Ri</creator><creator>Jeon, Yeong‐Eui</creator><creator>Bak, Eun‐Jung</creator><creator>Yoo, Yun‐Jung</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5661-9596</orcidid><orcidid>https://orcid.org/0000-0002-7976-8594</orcidid><orcidid>https://orcid.org/0000-0002-0045-9597</orcidid></search><sort><creationdate>202404</creationdate><title>Periodontitis deteriorates renal fibrosis and macrophage infiltration in rats with chronic kidney disease</title><author>Lee, Youn Soo ; Kim, Ae Ri ; Jeon, Yeong‐Eui ; Bak, Eun‐Jung ; Yoo, Yun‐Jung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3131-92a6b167d9daffed9a3e02445b1981fb8dd0d437de37965a34ef69db9c47eb3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alveolar bone</topic><topic>Animals</topic><topic>chronic kidney disease</topic><topic>Creatinine</topic><topic>Creatinine - blood</topic><topic>Fibrosis</topic><topic>Glomerulus</topic><topic>Gum disease</topic><topic>Kidney - pathology</topic><topic>Kidney diseases</topic><topic>macrophage</topic><topic>Macrophages</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Nephrectomy</topic><topic>Periodontitis</topic><topic>Periodontitis - complications</topic><topic>Periodontitis - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Renal function</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - etiology</topic><topic>Renal Insufficiency, Chronic - pathology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Youn Soo</creatorcontrib><creatorcontrib>Kim, Ae Ri</creatorcontrib><creatorcontrib>Jeon, Yeong‐Eui</creatorcontrib><creatorcontrib>Bak, Eun‐Jung</creatorcontrib><creatorcontrib>Yoo, Yun‐Jung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Youn Soo</au><au>Kim, Ae Ri</au><au>Jeon, Yeong‐Eui</au><au>Bak, Eun‐Jung</au><au>Yoo, Yun‐Jung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontitis deteriorates renal fibrosis and macrophage infiltration in rats with chronic kidney disease</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2024-04</date><risdate>2024</risdate><volume>30</volume><issue>3</issue><spage>1497</spage><epage>1505</epage><pages>1497-1505</pages><issn>1354-523X</issn><issn>1601-0825</issn><eissn>1601-0825</eissn><abstract>Objective
The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy (Nx)‐induced chronic kidney disease (CKD).
Methods
Rats were divided into sham surgery (Sham), Sham with tooth ligation (ShamL), Nx, and NxL groups. Periodontitis was induced by tooth ligation at 16‐week olds. Creatinine, alveolar bone area, and renal histopathology were analyzed at 20‐week olds.
Results
Creatinine did not differ between the Sham and ShamL groups or between the Nx and NxL groups. The ShamL and NxL groups (both p = 0.002) had less alveolar bone area than the Sham group. The NxL group had fewer glomeruli than the Nx group (p < 0.000). The periodontitis groups demonstrated more tubulointerstitial fibrosis (Sham vs. ShamL p = 0.002, Nx vs. NxL p < 0.000) and macrophage infiltration (Sham vs. ShamL p = 0.002, Nx vs. NxL p = 0.006) than the groups without periodontitis. Only the NxL group had greater renal TNFα expression than the Sham group (p < 0.003).
Conclusions
These suggest that periodontitis increases renal fibrosis and inflammation in the presence or absence of CKD but does not affect renal function. Periodontitis also increases TNFα expression in the presence of CKD.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36905098</pmid><doi>10.1111/odi.14561</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5661-9596</orcidid><orcidid>https://orcid.org/0000-0002-7976-8594</orcidid><orcidid>https://orcid.org/0000-0002-0045-9597</orcidid></addata></record> |
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| subjects | Alveolar bone Animals chronic kidney disease Creatinine Creatinine - blood Fibrosis Glomerulus Gum disease Kidney - pathology Kidney diseases macrophage Macrophages Macrophages - pathology Male Nephrectomy Periodontitis Periodontitis - complications Periodontitis - pathology Rats Rats, Sprague-Dawley Renal function Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - pathology Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α |
| title | Periodontitis deteriorates renal fibrosis and macrophage infiltration in rats with chronic kidney disease |
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