Periodontitis deteriorates renal fibrosis and macrophage infiltration in rats with chronic kidney disease

Objective The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy (Nx)‐induced chronic kidney disease (CKD). Methods Rats were divided into sham surgery (Sham), Sham with tooth ligation (ShamL), Nx, and NxL groups. Periodontitis was induced by tooth ligation at 16‐week olds. Creatinine, alveolar bone area, and renal histopathology were analyzed at 20‐week olds. Results Creatinine did not differ between the Sham and ShamL groups or between the Nx and NxL groups. The ShamL and NxL groups (both p = 0.002) had less alveolar bone area than the Sham group. The NxL group had fewer glomeruli than the Nx group (p