Painless progressive mononeuritis multiplex secondary to AML associated neuroleukemiosis
Neuroleukemiosis describes peripheral nerve involvement secondary to leukemic infiltration, a rare complication of leukemia with various clinical presentations, leading to diagnostic challenges for hematologists and neurologists. We present two cases of painless progressive mononeuritis multiplex se...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 2023-04, Vol.377, p.578061-578061, Article 578061 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 578061 |
|---|---|
| container_issue | |
| container_start_page | 578061 |
| container_title | Journal of neuroimmunology |
| container_volume | 377 |
| creator | Nagaratnam, Sai Harinesan, Nimalan Wijesinghe, Rajiv Wong-Doo, Nicole Lyons, Alison Morris, Katrina Triplett, James |
| description | Neuroleukemiosis describes peripheral nerve involvement secondary to leukemic infiltration, a rare complication of leukemia with various clinical presentations, leading to diagnostic challenges for hematologists and neurologists. We present two cases of painless progressive mononeuritis multiplex secondary to neuroleukemiosis. A literature review of previously reported cases of neuroleukemiosis was undertaken. Neuroleukemiosis may present as a progressive mononeuritis multiplex. The diagnosis of neuroleukemiosis requires a high index of suspicion and be aided by repeated CSF analysis.
•Neuroleukemiosis describes the leukemic infiltration of peripheral nerves.•Presentations include painless mono-neuropathies, formations of a chloroma and painful radiculoplexopathies.•Tissue sampling through nerve biopsy remains the gold standard for diagnosis though yield can be limited.•Neuroleukemiosis tends to portend a poor prognosis. |
| doi_str_mv | 10.1016/j.jneuroim.2023.578061 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2786102830</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165572823000474</els_id><sourcerecordid>2786102830</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-70fe8c014fca2156e71126d1646b1265db2433967e0e9eb1b079ca49ccb1a62a3</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EoqXwF6qMLCk-J3GSjariSyqCASQ2y3GuyCWJiy9B8O9xaWFluhue-3gfxqbAZ8BBXqxn6w4H72w7E1wksywvuIQDNoYiF3GRCjhk4wBmcZaLYsROiNacQ5ak5TEbJbIoi4SnY_byqG3XIFG08e7Vh8Z-YNS6zm3X295S1A5NbzcNfkaExnW19l9R76L5_TLSRM5Y3WMd_XzT4PCGrXVk6ZQdrXRDeLavE_Z8ffW0uI2XDzd3i_kyNglkfZzzFRaGQ7oyWkAmMQcQsgaZyio0WV2JNElKmSPHEiuoeF4anZbGVKCl0MmEne_2hv_fB6RetZYMNo3u0A2kRF5I4CKkDajcocY7Io8rtfG2DXEUcLW1qtbq16raWlU7q2Fwur8xVC3Wf2O_GgNwuQMwJP2w6BUZi53B2no0vaqd_e_GNzTZjho</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2786102830</pqid></control><display><type>article</type><title>Painless progressive mononeuritis multiplex secondary to AML associated neuroleukemiosis</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Nagaratnam, Sai ; Harinesan, Nimalan ; Wijesinghe, Rajiv ; Wong-Doo, Nicole ; Lyons, Alison ; Morris, Katrina ; Triplett, James</creator><creatorcontrib>Nagaratnam, Sai ; Harinesan, Nimalan ; Wijesinghe, Rajiv ; Wong-Doo, Nicole ; Lyons, Alison ; Morris, Katrina ; Triplett, James</creatorcontrib><description>Neuroleukemiosis describes peripheral nerve involvement secondary to leukemic infiltration, a rare complication of leukemia with various clinical presentations, leading to diagnostic challenges for hematologists and neurologists. We present two cases of painless progressive mononeuritis multiplex secondary to neuroleukemiosis. A literature review of previously reported cases of neuroleukemiosis was undertaken. Neuroleukemiosis may present as a progressive mononeuritis multiplex. The diagnosis of neuroleukemiosis requires a high index of suspicion and be aided by repeated CSF analysis.
•Neuroleukemiosis describes the leukemic infiltration of peripheral nerves.•Presentations include painless mono-neuropathies, formations of a chloroma and painful radiculoplexopathies.•Tissue sampling through nerve biopsy remains the gold standard for diagnosis though yield can be limited.•Neuroleukemiosis tends to portend a poor prognosis.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2023.578061</identifier><identifier>PMID: 36898304</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Humans ; Leukemia ; Leukemia, Myeloid, Acute - complications ; Leukemic Infiltration - complications ; Mononeuritis multiplex ; Mononeuropathies - complications ; Mononeuropathies - diagnosis ; Neuroleukemiosis ; Neuropathy ; Peripheral Nerves</subject><ispartof>Journal of neuroimmunology, 2023-04, Vol.377, p.578061-578061, Article 578061</ispartof><rights>2023</rights><rights>Crown Copyright © 2023. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c315t-70fe8c014fca2156e71126d1646b1265db2433967e0e9eb1b079ca49ccb1a62a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2023.578061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36898304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagaratnam, Sai</creatorcontrib><creatorcontrib>Harinesan, Nimalan</creatorcontrib><creatorcontrib>Wijesinghe, Rajiv</creatorcontrib><creatorcontrib>Wong-Doo, Nicole</creatorcontrib><creatorcontrib>Lyons, Alison</creatorcontrib><creatorcontrib>Morris, Katrina</creatorcontrib><creatorcontrib>Triplett, James</creatorcontrib><title>Painless progressive mononeuritis multiplex secondary to AML associated neuroleukemiosis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Neuroleukemiosis describes peripheral nerve involvement secondary to leukemic infiltration, a rare complication of leukemia with various clinical presentations, leading to diagnostic challenges for hematologists and neurologists. We present two cases of painless progressive mononeuritis multiplex secondary to neuroleukemiosis. A literature review of previously reported cases of neuroleukemiosis was undertaken. Neuroleukemiosis may present as a progressive mononeuritis multiplex. The diagnosis of neuroleukemiosis requires a high index of suspicion and be aided by repeated CSF analysis.
•Neuroleukemiosis describes the leukemic infiltration of peripheral nerves.•Presentations include painless mono-neuropathies, formations of a chloroma and painful radiculoplexopathies.•Tissue sampling through nerve biopsy remains the gold standard for diagnosis though yield can be limited.•Neuroleukemiosis tends to portend a poor prognosis.</description><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Acute - complications</subject><subject>Leukemic Infiltration - complications</subject><subject>Mononeuritis multiplex</subject><subject>Mononeuropathies - complications</subject><subject>Mononeuropathies - diagnosis</subject><subject>Neuroleukemiosis</subject><subject>Neuropathy</subject><subject>Peripheral Nerves</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXwF6qMLCk-J3GSjariSyqCASQ2y3GuyCWJiy9B8O9xaWFluhue-3gfxqbAZ8BBXqxn6w4H72w7E1wksywvuIQDNoYiF3GRCjhk4wBmcZaLYsROiNacQ5ak5TEbJbIoi4SnY_byqG3XIFG08e7Vh8Z-YNS6zm3X295S1A5NbzcNfkaExnW19l9R76L5_TLSRM5Y3WMd_XzT4PCGrXVk6ZQdrXRDeLavE_Z8ffW0uI2XDzd3i_kyNglkfZzzFRaGQ7oyWkAmMQcQsgaZyio0WV2JNElKmSPHEiuoeF4anZbGVKCl0MmEne_2hv_fB6RetZYMNo3u0A2kRF5I4CKkDajcocY7Io8rtfG2DXEUcLW1qtbq16raWlU7q2Fwur8xVC3Wf2O_GgNwuQMwJP2w6BUZi53B2no0vaqd_e_GNzTZjho</recordid><startdate>20230415</startdate><enddate>20230415</enddate><creator>Nagaratnam, Sai</creator><creator>Harinesan, Nimalan</creator><creator>Wijesinghe, Rajiv</creator><creator>Wong-Doo, Nicole</creator><creator>Lyons, Alison</creator><creator>Morris, Katrina</creator><creator>Triplett, James</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230415</creationdate><title>Painless progressive mononeuritis multiplex secondary to AML associated neuroleukemiosis</title><author>Nagaratnam, Sai ; Harinesan, Nimalan ; Wijesinghe, Rajiv ; Wong-Doo, Nicole ; Lyons, Alison ; Morris, Katrina ; Triplett, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-70fe8c014fca2156e71126d1646b1265db2433967e0e9eb1b079ca49ccb1a62a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia, Myeloid, Acute - complications</topic><topic>Leukemic Infiltration - complications</topic><topic>Mononeuritis multiplex</topic><topic>Mononeuropathies - complications</topic><topic>Mononeuropathies - diagnosis</topic><topic>Neuroleukemiosis</topic><topic>Neuropathy</topic><topic>Peripheral Nerves</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagaratnam, Sai</creatorcontrib><creatorcontrib>Harinesan, Nimalan</creatorcontrib><creatorcontrib>Wijesinghe, Rajiv</creatorcontrib><creatorcontrib>Wong-Doo, Nicole</creatorcontrib><creatorcontrib>Lyons, Alison</creatorcontrib><creatorcontrib>Morris, Katrina</creatorcontrib><creatorcontrib>Triplett, James</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagaratnam, Sai</au><au>Harinesan, Nimalan</au><au>Wijesinghe, Rajiv</au><au>Wong-Doo, Nicole</au><au>Lyons, Alison</au><au>Morris, Katrina</au><au>Triplett, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Painless progressive mononeuritis multiplex secondary to AML associated neuroleukemiosis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2023-04-15</date><risdate>2023</risdate><volume>377</volume><spage>578061</spage><epage>578061</epage><pages>578061-578061</pages><artnum>578061</artnum><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Neuroleukemiosis describes peripheral nerve involvement secondary to leukemic infiltration, a rare complication of leukemia with various clinical presentations, leading to diagnostic challenges for hematologists and neurologists. We present two cases of painless progressive mononeuritis multiplex secondary to neuroleukemiosis. A literature review of previously reported cases of neuroleukemiosis was undertaken. Neuroleukemiosis may present as a progressive mononeuritis multiplex. The diagnosis of neuroleukemiosis requires a high index of suspicion and be aided by repeated CSF analysis.
•Neuroleukemiosis describes the leukemic infiltration of peripheral nerves.•Presentations include painless mono-neuropathies, formations of a chloroma and painful radiculoplexopathies.•Tissue sampling through nerve biopsy remains the gold standard for diagnosis though yield can be limited.•Neuroleukemiosis tends to portend a poor prognosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36898304</pmid><doi>10.1016/j.jneuroim.2023.578061</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2023-04, Vol.377, p.578061-578061, Article 578061 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2786102830 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Humans Leukemia Leukemia, Myeloid, Acute - complications Leukemic Infiltration - complications Mononeuritis multiplex Mononeuropathies - complications Mononeuropathies - diagnosis Neuroleukemiosis Neuropathy Peripheral Nerves |
| title | Painless progressive mononeuritis multiplex secondary to AML associated neuroleukemiosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T03%3A02%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Painless%20progressive%20mononeuritis%20multiplex%20secondary%20to%20AML%20associated%20neuroleukemiosis&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Nagaratnam,%20Sai&rft.date=2023-04-15&rft.volume=377&rft.spage=578061&rft.epage=578061&rft.pages=578061-578061&rft.artnum=578061&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/j.jneuroim.2023.578061&rft_dat=%3Cproquest_cross%3E2786102830%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2786102830&rft_id=info:pmid/36898304&rft_els_id=S0165572823000474&rfr_iscdi=true |