A ratiometric fluorescent probe for fast detection and bioimaging of formaldehyde

A ratiometric fluorescent probe for fast detection and bioimaging of formaldehyde

A novel ratiometric probe ( SWJT-10 ) based on isophorone derivatives has been designed and synthesized for the detection of formaldehyde (FA). This probe displayed an obvious ratiometric fluorescence response to FA with a blue shift from the NIR (680 nm) to the yellow light region (600 nm) in aqueo...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-03, Vol.21 (1), p.2167-2171
Hauptverfasser: Lin, Nai-Jie, Wu, Huan, Peng, Jing, Yang, Shu-Han, Tan, Rui, Peng, Yu, Wang, Ya-Wen
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Aqueous solutions
Fluorescence
Fluorescent Dyes
Fluorescent indicators
Formaldehyde
HeLa Cells
Humans
Medical imaging
Selectivity
Zebrafish
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Zusammenfassung:A novel ratiometric probe ( SWJT-10 ) based on isophorone derivatives has been designed and synthesized for the detection of formaldehyde (FA). This probe displayed an obvious ratiometric fluorescence response to FA with a blue shift from the NIR (680 nm) to the yellow light region (600 nm) in aqueous solution. And it showed good selectivity, high sensitivity and a fast response to FA (less than 5 s) due to a new recognition mechanism. Moreover, SWJT-10 has been applied to monitor FA in living cells and zebrafish. A novel ratiometric fluorescent probe has been developed for rapid detection of formaldehyde based on a new recognition mechanism.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob02314h