Extranodal natural killer/T‐cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets

(A) Correlation matrix of unsupervised co‐regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co‐regulated genes corresponded to the following: Inflammatory cells; Epstein–Barr virus; B‐cells; Cytotoxic T‐cells; T‐cells; and Proliferation. (B) Analysi...

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Veröffentlicht in:American journal of hematology 2023-06, Vol.98 (6), p.E134-E138
Hauptverfasser: Gonzalez Barca, Eva, Tomás‐Roca, Laura, Esteve, Anna, Rodriguez, Marta, Gato, Lucía, Alonso‐Alonso, Ruth, Martin Garcia‐Sancho, Alejandro, Cordoba, Raul, Monter‐Rovira, Anna, Bastos‐Oreiro, Mariana, Bergua Burgues, Juan Miguel, Sayas, Maria Jose, Viguria Alegria, Maria Cruz, Sanchez‐Blanco, Jose Javier, Roig Pellicer, Monica, Luzardo Henriquez, Hugo Daniel, Oña, Raquel, Cabezudo, Maria Elena, Infante, Maria Stefania, Queizán Hernández, José Antonio, Sanz‐Pamplona, Rebeca, Blanco, Oscar, Mozos, Ana, Climent, Fina, Piris, Miguel Angel
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container_issue 6
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container_title American journal of hematology
container_volume 98
creator Gonzalez Barca, Eva
Tomás‐Roca, Laura
Esteve, Anna
Rodriguez, Marta
Gato, Lucía
Alonso‐Alonso, Ruth
Martin Garcia‐Sancho, Alejandro
Cordoba, Raul
Monter‐Rovira, Anna
Bastos‐Oreiro, Mariana
Bergua Burgues, Juan Miguel
Sayas, Maria Jose
Viguria Alegria, Maria Cruz
Sanchez‐Blanco, Jose Javier
Roig Pellicer, Monica
Luzardo Henriquez, Hugo Daniel
Oña, Raquel
Cabezudo, Maria Elena
Infante, Maria Stefania
Queizán Hernández, José Antonio
Sanz‐Pamplona, Rebeca
Blanco, Oscar
Mozos, Ana
Climent, Fina
Piris, Miguel Angel
description (A) Correlation matrix of unsupervised co‐regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co‐regulated genes corresponded to the following: Inflammatory cells; Epstein–Barr virus; B‐cells; Cytotoxic T‐cells; T‐cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.
doi_str_mv 10.1002/ajh.26904
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source Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Cell proliferation
Cytotoxicity
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - genetics
Epstein-Barr Virus Infections - pathology
Genomic analysis
Hematology
Herpesvirus 4, Human - genetics
Humans
Inflammation
Killer Cells, Natural - pathology
Lymphoma
Lymphoma, Extranodal NK-T-Cell - therapy
Mutation
Natural killer cells
T-cell lymphoma
Therapeutic targets
title Extranodal natural killer/T‐cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets
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