Extranodal natural killer/T‐cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets
(A) Correlation matrix of unsupervised co‐regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co‐regulated genes corresponded to the following: Inflammatory cells; Epstein–Barr virus; B‐cells; Cytotoxic T‐cells; T‐cells; and Proliferation. (B) Analysi...
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container_title | American journal of hematology |
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creator | Gonzalez Barca, Eva Tomás‐Roca, Laura Esteve, Anna Rodriguez, Marta Gato, Lucía Alonso‐Alonso, Ruth Martin Garcia‐Sancho, Alejandro Cordoba, Raul Monter‐Rovira, Anna Bastos‐Oreiro, Mariana Bergua Burgues, Juan Miguel Sayas, Maria Jose Viguria Alegria, Maria Cruz Sanchez‐Blanco, Jose Javier Roig Pellicer, Monica Luzardo Henriquez, Hugo Daniel Oña, Raquel Cabezudo, Maria Elena Infante, Maria Stefania Queizán Hernández, José Antonio Sanz‐Pamplona, Rebeca Blanco, Oscar Mozos, Ana Climent, Fina Piris, Miguel Angel |
description | (A) Correlation matrix of unsupervised co‐regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co‐regulated genes corresponded to the following: Inflammatory cells; Epstein–Barr virus; B‐cells; Cytotoxic T‐cells; T‐cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR. |
doi_str_mv | 10.1002/ajh.26904 |
format | Article |
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subjects | Cell proliferation Cytotoxicity Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - pathology Genomic analysis Hematology Herpesvirus 4, Human - genetics Humans Inflammation Killer Cells, Natural - pathology Lymphoma Lymphoma, Extranodal NK-T-Cell - therapy Mutation Natural killer cells T-cell lymphoma Therapeutic targets |
title | Extranodal natural killer/T‐cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets |
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