Extranodal natural killer/T‐cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets

(A) Correlation matrix of unsupervised co‐regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co‐regulated genes corresponded to the following: Inflammatory cells; Epstein–Barr virus; B‐cells; Cytotoxic T‐cells; T‐cells; and Proliferation. (B) Analysi...

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Veröffentlicht in:American journal of hematology 2023-06, Vol.98 (6), p.E134-E138
Hauptverfasser: Gonzalez Barca, Eva, Tomás‐Roca, Laura, Esteve, Anna, Rodriguez, Marta, Gato, Lucía, Alonso‐Alonso, Ruth, Martin Garcia‐Sancho, Alejandro, Cordoba, Raul, Monter‐Rovira, Anna, Bastos‐Oreiro, Mariana, Bergua Burgues, Juan Miguel, Sayas, Maria Jose, Viguria Alegria, Maria Cruz, Sanchez‐Blanco, Jose Javier, Roig Pellicer, Monica, Luzardo Henriquez, Hugo Daniel, Oña, Raquel, Cabezudo, Maria Elena, Infante, Maria Stefania, Queizán Hernández, José Antonio, Sanz‐Pamplona, Rebeca, Blanco, Oscar, Mozos, Ana, Climent, Fina, Piris, Miguel Angel
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Sprache:eng
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Zusammenfassung:(A) Correlation matrix of unsupervised co‐regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co‐regulated genes corresponded to the following: Inflammatory cells; Epstein–Barr virus; B‐cells; Cytotoxic T‐cells; T‐cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.26904