Dissemination of methicillin-resistant Staphylococcus aureus USA300 ST8/PVL- positive in breast infections in a Brazilian region

•The USA300- North American epidemic methicillin-resistant strains clone carrying SCCmecIVa, ACME, t008, ST8, and Panton-Valentine leukocidin genes was predominant in breast infections.•The patients showed no apparent epidemiological relationship.•The USA300 strains were resistant to erythromycin, levofloxacin, and ciprofloxacin.•The new ST8005 was described in MRSA isolated from breast infection. We aimed to analyze the molecular epidemiology of 46 methicillin-resistant Staphylococcus aureus (MRSA) isolated from breast infections. The USA300 lineage carrying SCCmecIVa, arginine catabolic mobile element, t008, ST8, and Panton-Valentine leukocidin genes was predominant (93%). This is the first study that describes the spread of the USA300 methicillin-resistant Staphylococcus aureus clone in breast infections in Brazil.