Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea

ObjectiveTo evaluate the effect of surgical intervention on serum insulin-like growth factor 1 levels in patients with obstructive sleep apnoea.MethodsA prospective study was conducted in a tertiary care hospital of adult patients with obstructive sleep apnoea for whom continuous positive airway pre...

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Veröffentlicht in:Journal of laryngology and otology 2023-11, Vol.137 (11), p.1222-1225
Hauptverfasser: Jaiswal, A S, Valappil, B V, Gupta, Y, Sikka, K, Thakar, A, Verma, H
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Sprache:eng
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Zusammenfassung:ObjectiveTo evaluate the effect of surgical intervention on serum insulin-like growth factor 1 levels in patients with obstructive sleep apnoea.MethodsA prospective study was conducted in a tertiary care hospital of adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy failed or was refused. All patients underwent polysomnography and serum insulin-like growth factor 1 evaluation pre-operatively and at three months post-operatively. The site of surgery was determined using Müller's manoeuvre and ApneaGraph AG 200.ResultsFifteen patients were included with a mean age of 38 years: 11 males and 4 females. The mean pre-operative Apnoea–Hypopnoea Index using polysomnography was 53.7 events per hour, and the mean post-operative Apnoea–Hypopnoea Index at three months was 15.3 events per hour (p = 0.0001). The mean pre-operative serum insulin-like growth factor 1 was 160.2 μg/l, while the mean post-operative value was 236.98 μg/l (p = 0.005).ConclusionIn adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy fails, site-specific surgical intervention to treat the obstruction leads to an increase in serum insulin-like growth factor 1 levels.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215123000348