Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study

Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study

We aimed to analyze intensive care unit (ICU)-acquired pneumonia according to 7 definitions, estimating associated hospital mortality. This cohort study was nested within an international randomized trial, evaluating the effect of probiotics on ICU-acquired pneumonia in 2650 mechanically ventilated...

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Veröffentlicht in:Journal of critical care 2023-06, Vol.75, p.154284-154284, Article 154284
Hauptverfasser: Johnstone, Jennie, Muscedere, John, Dionne, Joanna, Duan, Erick, Rochwerg, Bram, Centofanti, John, Oczkowski, Simon, Lauzier, Francois, Marshall, John, Heels-Ansdell, Diane, Daneman, Nick, Mehta, Sangeeta, Arabi, Yaseen, Zytaruk, Nicole, Dodek, Peter, Adhikari, Neill K., Karachi, Tim, Charbonney, Emmanuel, Stelfox, Henry T., Kristof, Arnold S., Ball, Ian, Hand, Lori, Fowler, Rob, Zarychanski, Ryan, Arnaud, Charles St, Takaoka, Alyson, Kutsogiannis, James, Khwaja, Kosar, Sligl, Wendy, Loubani, Osama, Tsang, Jennifer, Lamarche, Daphnee, Bowdish, Dawn, Surette, Michael, Cook, Deborah
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Cohort analysis
Cohort Studies
Critical care
Definitions
Extubation
Hospital Mortality
Humans
Infections
Intensive care
Intensive Care Units
Mortality
Nosocomial infections
Pneumonia
Pneumonia, Ventilator-Associated - microbiology
Probiotics
Ventilator associated pneumonia
Ventilators
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Zusammenfassung:We aimed to analyze intensive care unit (ICU)-acquired pneumonia according to 7 definitions, estimating associated hospital mortality. This cohort study was nested within an international randomized trial, evaluating the effect of probiotics on ICU-acquired pneumonia in 2650 mechanically ventilated adults. Each clinically suspected pneumonia was adjudicated by two physicians blinded to allocation and center. The primary outcome was ventilator-associated pneumonia (VAP) informed by ventilation for ≥2 days, new, progressive or persistent infiltrate plus 2 of: temperature > 38 °C or 
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2023.154284