Focal adhesion signaling pathway involved in skin immune response of tongue sole Cynoglossus semilaevis to Vibrio vulnificus infection

Focal adhesion signaling pathway involved in skin immune response of tongue sole Cynoglossus semilaevis to Vibrio vulnificus infection

Focal adhesion (FA) plays a key role in cell adhesion, migration and antibacterial immune, but it remained unclear in fish. In this study, half-smooth tongue sole Cynoglossus semilaevis were infected with Vibrio vulnificus, and then immune-related protein in the skin, especially for FA signaling pat...

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Veröffentlicht in:Fish & shellfish immunology 2023-04, Vol.135, p.108651-108651, Article 108651
Hauptverfasser: Liu, Houfu, Hu, Xiucai, Lian, Zhengyi, Luo, Zhang, Lv, Aijun, Tan, Jing
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Adhesion
Cynoglossus semilaevis
Fish Diseases
Fish Proteins
Flatfishes
Flounder - metabolism
Focal adhesion
Focal Adhesions - metabolism
Immunity
Vibrio - physiology
Vibrio Infections
Vibrio vulnificus
Vinculin
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Zusammenfassung:Focal adhesion (FA) plays a key role in cell adhesion, migration and antibacterial immune, but it remained unclear in fish. In this study, half-smooth tongue sole Cynoglossus semilaevis were infected with Vibrio vulnificus, and then immune-related protein in the skin, especially for FA signaling pathway were screened and identified by iTRAQ analysis. Results showed that the differentially expressed proteins (DEPs) in skin immune response (eg., ITGA6, FN, COCH, AMBP, COL6A1, COL6A3, COL6A6, LAMB1, LAMC1, FLMNA) were firstly found in FA signaling pathway. Furthermore, the validation analysis of FA-related genes were basically consistent with the iTRAQ data at 36 hpi (r = 0.678, p 
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2023.108651