Clinical performance comparison of two medium cut‐off dialyzers

Clinical performance comparison of two medium cut‐off dialyzers

Introduction Medium‐cut‐off (MCO) dialyzers may beneficially impact outcomes in patients on hemodialysis. Methods In a randomized, controlled trial in maintenance hemodialysis patients, the new Nipro ELISIO‐17HX MCO dialyzer was compared to the Baxter Theranova 400 filter regarding middle molecule r...

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Veröffentlicht in:Therapeutic apheresis and dialysis 2023-04, Vol.27 (2), p.284-292
Hauptverfasser: Krieter, Detlef H., Rüth, Marieke, Lemke, Horst‐Dieter, Wanner, Christoph
Format: Artikel
Sprache:eng
Schlagworte:
Albumins
Cephalosporins
dialysis adequacy
end‐stage kidney disease
free light chains
hemodialysis
Humans
medium cut‐off dialyzer
Myoglobin
Renal Dialysis - instrumentation
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Zusammenfassung:Introduction Medium‐cut‐off (MCO) dialyzers may beneficially impact outcomes in patients on hemodialysis. Methods In a randomized, controlled trial in maintenance hemodialysis patients, the new Nipro ELISIO‐17HX MCO dialyzer was compared to the Baxter Theranova 400 filter regarding middle molecule removal. Furthermore, the suitability of two assays for free lambda‐light chain (λFLC) detection (Freelite vs. N‐Latex) was verified. Results ELISIO‐HX achieved slightly lower reduction ratios for β2‐microglobulin (71.8 ± 6.0 vs. 75.3 ± 5.8%; p = 0.001), myoglobin (54.7 ± 8.6 vs. 64.9 ± 8.7%; p 
ISSN:1744-9979
1744-9987
DOI:10.1111/1744-9987.13919