Folic acid-modified reverse micelle-lipid nanocapsules overcome intestinal barriers and improve the oral delivery of peptides

The oral absorption of exenatide, a type 2 diabetes medication, can be increased by employing lipid nanocapsules (LNC). To increase mucus permeability and exenatide intestinal absorption, reverse micelle lipid nanocapsules (RM-LNC) were prepared and their surface was modified with DSPE-PEG-FA. The R...

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Veröffentlicht in:	Drug delivery 2023-12, Vol.30 (1), p.2181744-2181744
Hauptverfasser:	He, Jibiao, Ding, Ruihuan, Tao, Yuping, Zhao, Zhenyu, Yuan, Ranran, Zhang, Houqian, Wang, Aiping, Sun, Kaoxiang, Li, Youxin, Shi, Yanan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caco-2 Cells Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - drug therapy Exenatide Folic Acid Humans Intestines lipid nanocapsules Lipids Mice Micelles Nanocapsules Nanoparticle Drug Delivery System oral administration Peptides Rats reverse micelle targeted drug delivery
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