RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity to Spliceosome Inhibition

In lung adenocarcinoma (LUAD), loss-of-function mutations in the splicing factor RBM10 frequently co-occur with oncogenic EGFR mutations. A detailed understanding of the functional consequences and therapeutic impact of RBM10 loss in EGFR-mutant LUAD could help identify more effective treatment stra...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2023-05, Vol.83 (9), p.1490-1502
Hauptverfasser:	Bao, Yufang, Zhang, Sirui, Zhang, Xiaoyu, Pan, Yunjian, Yan, Yueren, Wang, Ning, Ren, Yunpeng, Zuo, Ji, Zong, Wei-Xing, Wang, Zefeng, Wang, Yongbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma of Lung - genetics Animals ErbB Receptors - metabolism Lung Neoplasms - pathology Mice Mutation RNA Splicing Factors - genetics Spliceosomes - metabolism Tumor Suppressor Protein p53 - genetics
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