Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome...

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Veröffentlicht in:Clinical & translational oncology 2023-07, Vol.25 (7), p.2015-2042
Hauptverfasser: Farzaneh, Maryam, Nasrolahi, Ava, Ghaedrahmati, Farhoodeh, Masoodi, Tariq, Najafi, Sajad, Sheykhi-Sabzehpoush, Mohadeseh, Dari, Mahrokh Abouali Gale, Radoszkiewicz, Klaudia, Uddin, Shahab, Azizidoost, Shirin, Khoshnam, Seyed Esmaeil
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container_end_page 2042
container_issue 7
container_start_page 2015
container_title Clinical & translational oncology
container_volume 25
creator Farzaneh, Maryam
Nasrolahi, Ava
Ghaedrahmati, Farhoodeh
Masoodi, Tariq
Najafi, Sajad
Sheykhi-Sabzehpoush, Mohadeseh
Dari, Mahrokh Abouali Gale
Radoszkiewicz, Klaudia
Uddin, Shahab
Azizidoost, Shirin
Khoshnam, Seyed Esmaeil
description Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
doi_str_mv 10.1007/s12094-023-03110-y
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Medicine & Public Health
Oncology
Review Article
title Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells
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