Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome...
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Veröffentlicht in: | Clinical & translational oncology 2023-07, Vol.25 (7), p.2015-2042 |
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container_issue | 7 |
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container_title | Clinical & translational oncology |
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creator | Farzaneh, Maryam Nasrolahi, Ava Ghaedrahmati, Farhoodeh Masoodi, Tariq Najafi, Sajad Sheykhi-Sabzehpoush, Mohadeseh Dari, Mahrokh Abouali Gale Radoszkiewicz, Klaudia Uddin, Shahab Azizidoost, Shirin Khoshnam, Seyed Esmaeil |
description | Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers. |
doi_str_mv | 10.1007/s12094-023-03110-y |
format | Article |
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title | Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells |
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