Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome...

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Veröffentlicht in:	Clinical & translational oncology 2023-07, Vol.25 (7), p.2015-2042
Hauptverfasser:	Farzaneh, Maryam, Nasrolahi, Ava, Ghaedrahmati, Farhoodeh, Masoodi, Tariq, Najafi, Sajad, Sheykhi-Sabzehpoush, Mohadeseh, Dari, Mahrokh Abouali Gale, Radoszkiewicz, Klaudia, Uddin, Shahab, Azizidoost, Shirin, Khoshnam, Seyed Esmaeil
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis Female Humans Medicine Medicine & Public Health MicroRNAs - genetics Neoplasms - genetics Oncology Review Article RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger
Online-Zugang:	Volltext
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Zusammenfassung:	Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
ISSN:	1699-3055 1699-3055
DOI:	10.1007/s12094-023-03110-y