Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer

High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to initial treatment, acquired resistance is common. We undertook a multiomics approach to interrogate molecular diversity in end-stage...

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Veröffentlicht in:Nature genetics 2023-03, Vol.55 (3), p.437-450
Hauptverfasser: Burdett, Nikki L., Willis, Madelynne O., Alsop, Kathryn, Hunt, Allison L., Pandey, Ahwan, Hamilton, Phineas T., Abulez, Tamara, Liu, Xuan, Hoang, Therese, Craig, Stuart, Fereday, Sian, Hendley, Joy, Garsed, Dale W., Milne, Katy, Kalaria, Shreena, Marshall, Ashley, Hood, Brian L., Wilson, Katlin N., Conrads, Kelly A., Pishas, Kathleen I., Ananda, Sumitra, Scott, Clare L., Antill, Yoland, McNally, Orla, Mileshkin, Linda, Hamilton, Anne, Au-Yeung, George, Devereux, Lisa, Thorne, Heather, Bild, Andrea, Bateman, Nicholas W., Maxwell, G. Larry, Chang, Jeffrey T., Conrads, Thomas P., Nelson, Brad H., Bowtell, David D. L., Christie, Elizabeth L.
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Sprache:eng
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