Plasma Connective Tissue Growth Factor as a Biomarker of Pulmonary Arterial Hypertension Associated With Congenital Heart Disease in Adults

Background: Connective tissue growth factor (CTGF) has diagnostic value for pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD) in children; however, its value in adult patients remains unclear. This study evaluated CTGF as a biomarker in adult PAH-CHD patients.Metho...

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Veröffentlicht in:	Circulation Journal 2023/03/24, Vol.87(4), pp.527-535
Hauptverfasser:	Liu, Wenshi, Hua, Ying, Zheng, Dongdong, Lv, Wenjing, Zhang, Wei, Chen, Qianqian, Huang, Rong, Li, Xiaofei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers Child Circulating biomarker Congenital heart disease Connective Tissue Growth Factor Familial Primary Pulmonary Hypertension - complications Heart Defects, Congenital - complications Heart Defects, Congenital - diagnosis Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - etiology Natriuretic Peptide, Brain Pulmonary arterial hypertension Pulmonary Arterial Hypertension - diagnosis Pulmonary Arterial Hypertension - etiology
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Zusammenfassung:	Background: Connective tissue growth factor (CTGF) has diagnostic value for pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD) in children; however, its value in adult patients remains unclear. This study evaluated CTGF as a biomarker in adult PAH-CHD patients.Methods and Results: Based on mean pulmonary artery pressure (mPAP), 56 CHD patients were divided into 3 groups: without PAH (W; mPAP
ISSN:	1346-9843 1347-4820 1347-4820
DOI:	10.1253/circj.CJ-22-0172