Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease
In patients with Parkinson’s disease, focused ultrasound ablation of the globus pallidus internus reduced motor impairment and dyskinesias at 3 months. Adverse events included dysarthria, gait disturbance, and loss of taste.
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| Veröffentlicht in: | The New England journal of medicine 2023-02, Vol.388 (8), p.683-693 |
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| container_title | The New England journal of medicine |
| container_volume | 388 |
| creator | Krishna, Vibhor Fishman, Paul S. Eisenberg, Howard M. Kaplitt, Michael Baltuch, Gordon Chang, Jin Woo Chang, Wei-Chieh Martinez Fernandez, Raul del Alamo, Marta Halpern, Casey H. Ghanouni, Pejman Eleopra, Roberto Cosgrove, Rees Guridi, Jorge Gwinn, Ryder Khemani, Pravin Lozano, Andres M. McDannold, Nathan Fasano, Alfonso Constantinescu, Marius Schlesinger, Ilana Dalvi, Arif Elias, W. Jeff |
| description | In patients with Parkinson’s disease, focused ultrasound ablation of the globus pallidus internus reduced motor impairment and dyskinesias at 3 months. Adverse events included dysarthria, gait disturbance, and loss of taste. |
| doi_str_mv | 10.1056/NEJMoa2202721 |
| format | Article |
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Jeff</creator><creatorcontrib>Krishna, Vibhor ; Fishman, Paul S. ; Eisenberg, Howard M. ; Kaplitt, Michael ; Baltuch, Gordon ; Chang, Jin Woo ; Chang, Wei-Chieh ; Martinez Fernandez, Raul ; del Alamo, Marta ; Halpern, Casey H. ; Ghanouni, Pejman ; Eleopra, Roberto ; Cosgrove, Rees ; Guridi, Jorge ; Gwinn, Ryder ; Khemani, Pravin ; Lozano, Andres M. ; McDannold, Nathan ; Fasano, Alfonso ; Constantinescu, Marius ; Schlesinger, Ilana ; Dalvi, Arif ; Elias, W. Jeff</creatorcontrib><description>In patients with Parkinson’s disease, focused ultrasound ablation of the globus pallidus internus reduced motor impairment and dyskinesias at 3 months. Adverse events included dysarthria, gait disturbance, and loss of taste.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2202721</identifier><identifier>PMID: 36812432</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Ablation ; Adverse events ; Clinical trials ; Dyskinesia ; Dyskinesias - etiology ; Dyskinesias - surgery ; FDA approval ; Gait ; Globus pallidus ; Globus Pallidus - surgery ; High-Intensity Focused Ultrasound Ablation ; Humans ; Magnetic resonance imaging ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Neurosurgery ; Pallidotomy ; Parkinson Disease ; Parkinson Disease - complications ; Parkinson Disease - surgery ; Parkinson's disease ; Surgery ; Surgery General ; Treatment Outcome ; Ultrasonic imaging ; Ultrasound</subject><ispartof>The New England journal of medicine, 2023-02, Vol.388 (8), p.683-693</ispartof><rights>Copyright © 2023 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2023 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-f492bbfb7d5d004f0b400d82958bcd1ad2ef749c55923819fbf522bebd55d3943</citedby><cites>FETCH-LOGICAL-c390t-f492bbfb7d5d004f0b400d82958bcd1ad2ef749c55923819fbf522bebd55d3943</cites><orcidid>0000-0002-4141-4192 ; 0000-0001-6089-2010 ; 0000-0001-5346-0180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2202721$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2202721$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36812432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krishna, Vibhor</creatorcontrib><creatorcontrib>Fishman, Paul S.</creatorcontrib><creatorcontrib>Eisenberg, Howard M.</creatorcontrib><creatorcontrib>Kaplitt, Michael</creatorcontrib><creatorcontrib>Baltuch, Gordon</creatorcontrib><creatorcontrib>Chang, Jin Woo</creatorcontrib><creatorcontrib>Chang, Wei-Chieh</creatorcontrib><creatorcontrib>Martinez Fernandez, Raul</creatorcontrib><creatorcontrib>del Alamo, Marta</creatorcontrib><creatorcontrib>Halpern, Casey H.</creatorcontrib><creatorcontrib>Ghanouni, Pejman</creatorcontrib><creatorcontrib>Eleopra, Roberto</creatorcontrib><creatorcontrib>Cosgrove, Rees</creatorcontrib><creatorcontrib>Guridi, Jorge</creatorcontrib><creatorcontrib>Gwinn, Ryder</creatorcontrib><creatorcontrib>Khemani, Pravin</creatorcontrib><creatorcontrib>Lozano, Andres M.</creatorcontrib><creatorcontrib>McDannold, Nathan</creatorcontrib><creatorcontrib>Fasano, Alfonso</creatorcontrib><creatorcontrib>Constantinescu, Marius</creatorcontrib><creatorcontrib>Schlesinger, Ilana</creatorcontrib><creatorcontrib>Dalvi, Arif</creatorcontrib><creatorcontrib>Elias, W. Jeff</creatorcontrib><title>Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In patients with Parkinson’s disease, focused ultrasound ablation of the globus pallidus internus reduced motor impairment and dyskinesias at 3 months. Adverse events included dysarthria, gait disturbance, and loss of taste.</description><subject>Ablation</subject><subject>Adverse events</subject><subject>Clinical trials</subject><subject>Dyskinesia</subject><subject>Dyskinesias - etiology</subject><subject>Dyskinesias - surgery</subject><subject>FDA approval</subject><subject>Gait</subject><subject>Globus pallidus</subject><subject>Globus Pallidus - surgery</subject><subject>High-Intensity Focused Ultrasound Ablation</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Pallidotomy</subject><subject>Parkinson Disease</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - surgery</subject><subject>Parkinson's disease</subject><subject>Surgery</subject><subject>Surgery General</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10L1OwzAUBWALgWgpjKwoEkJiCfi3iUdU2gJqgaGdIzu2pRQnLnYysPEavB5PgqEFCSS8XA-fju49ABwjeIEgG17ej-_mTmAMcYbRDugjRkhKKRzugj6EOE9pxkkPHISwgvEhyvdBjwxzhCnBfTBf-ErYxJlkap3sQvIorK1U_Exc2QWtkqVtvQiua1RyJa1oK9ckVROdf6qa4Jr317eQXFdBi6APwZ4RNuij7RyA5WS8GN2ks4fp7ehqlpaEwzY1lGMpjcwUUxBSAyWFUOWYs1yWCgmFtckoLxnjmOSIG2kYxlJLxZginJIBON_krr177nRoi7oKpbZWNNp1ocBZPJqhDMNIT__Qlet8E7f7UohhzllU6UaV3oXgtSnWvqqFfykQLD57Ln71HP3JNrWTtVY_-rvYCM42oK5D0ehV_U_QB0QNg6I</recordid><startdate>20230223</startdate><enddate>20230223</enddate><creator>Krishna, Vibhor</creator><creator>Fishman, Paul S.</creator><creator>Eisenberg, Howard M.</creator><creator>Kaplitt, Michael</creator><creator>Baltuch, Gordon</creator><creator>Chang, Jin Woo</creator><creator>Chang, Wei-Chieh</creator><creator>Martinez Fernandez, Raul</creator><creator>del Alamo, Marta</creator><creator>Halpern, Casey H.</creator><creator>Ghanouni, Pejman</creator><creator>Eleopra, Roberto</creator><creator>Cosgrove, Rees</creator><creator>Guridi, Jorge</creator><creator>Gwinn, Ryder</creator><creator>Khemani, Pravin</creator><creator>Lozano, Andres M.</creator><creator>McDannold, Nathan</creator><creator>Fasano, Alfonso</creator><creator>Constantinescu, Marius</creator><creator>Schlesinger, Ilana</creator><creator>Dalvi, Arif</creator><creator>Elias, W. 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| ispartof | The New England journal of medicine, 2023-02, Vol.388 (8), p.683-693 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Ablation Adverse events Clinical trials Dyskinesia Dyskinesias - etiology Dyskinesias - surgery FDA approval Gait Globus pallidus Globus Pallidus - surgery High-Intensity Focused Ultrasound Ablation Humans Magnetic resonance imaging Movement disorders Neurodegenerative diseases Neurology Neurosurgery Pallidotomy Parkinson Disease Parkinson Disease - complications Parkinson Disease - surgery Parkinson's disease Surgery Surgery General Treatment Outcome Ultrasonic imaging Ultrasound |
| title | Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease |
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