Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

In patients with Parkinson’s disease, focused ultrasound ablation of the globus pallidus internus reduced motor impairment and dyskinesias at 3 months. Adverse events included dysarthria, gait disturbance, and loss of taste.

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Veröffentlicht in:	The New England journal of medicine 2023-02, Vol.388 (8), p.683-693
Hauptverfasser:	Krishna, Vibhor, Fishman, Paul S., Eisenberg, Howard M., Kaplitt, Michael, Baltuch, Gordon, Chang, Jin Woo, Chang, Wei-Chieh, Martinez Fernandez, Raul, del Alamo, Marta, Halpern, Casey H., Ghanouni, Pejman, Eleopra, Roberto, Cosgrove, Rees, Guridi, Jorge, Gwinn, Ryder, Khemani, Pravin, Lozano, Andres M., McDannold, Nathan, Fasano, Alfonso, Constantinescu, Marius, Schlesinger, Ilana, Dalvi, Arif, Elias, W. Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adverse events Clinical trials Dyskinesia Dyskinesias - etiology Dyskinesias - surgery FDA approval Gait Globus pallidus Globus Pallidus - surgery High-Intensity Focused Ultrasound Ablation Humans Magnetic resonance imaging Movement disorders Neurodegenerative diseases Neurology Neurosurgery Pallidotomy Parkinson Disease Parkinson Disease - complications Parkinson Disease - surgery Parkinson's disease Surgery Surgery General Treatment Outcome Ultrasonic imaging Ultrasound
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Beschreibung
Zusammenfassung:	In patients with Parkinson’s disease, focused ultrasound ablation of the globus pallidus internus reduced motor impairment and dyskinesias at 3 months. Adverse events included dysarthria, gait disturbance, and loss of taste.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2202721