Ultra-precise weak measurement-based interfacial biosensors

In this study, an interfacial biosensing scheme with ultra-precision is proposed. The scheme uses weak measurement techniques to ensure ultra-high sensitivity of the sensing system while improving the stability of the system through self-referencing and pixel point averaging, thus achieving ultra-high detection accuracy of biological samples. In specific experiments, we have used the biosensor in this study to perform specific binding reaction experiments for protein A and Mouse IgG with a detection line of 2.71 ng/mL for IgG. In addition, the sensor is non-coated, simple in structure, easy to operate, and low in cost of use. [Display omitted] •An ultra-precise interfacial biosensing solution based on weak measurements.•High performance sensor on a common glass ‘chip’.•Improves sensor stability using self-referencing and pixel point averaging methods.•Enables label-free detection of biomolecules with an IgG detection limit of 2.71 ng/mL.