Detection of Second Primary Lymphoma in Late Diffuse Large B-cell Lymphoma Recurrences

Approximately one-third of patients with diffuse large B-cell lymphoma (DLBCL) relapse and often require salvage chemotherapy followed by autologous stem cell transplantation. In most cases, the clonal relationship between the first diagnosis and subsequent relapse is not assessed, thereby potential...

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Veröffentlicht in:	Modern pathology 2023-05, Vol.36 (5), p.100119-100119, Article 100119
Hauptverfasser:	Berendsen, Madeleine R., Bladel, Diede A.G. van, Hesius, Eva, de Groot, Fleur A., Kroeze, Leonie I., Rijntjes, Jos, Luijks, Jeroen A.C.W., Hoevenaars, Brigiet, Halilovic, Altuna, Nooijen, Peet, Bladel, Esther van, Jonge-Peeters, Susan de, Lensen, Chantal, Pruijt, Hans, van der Spek, Ellen, Vermaat, Joost S.P., Hess, Corine, Hebeda, Konnie M., Stevens, Wendy B.C., van Krieken, J. Han J.M., van den Brand, Michiel, Groenen, Patricia J.T.A., Scheijen, Blanca
Format:	Artikel
Sprache:	eng
Schlagworte:	clonality analysis diffuse large B-cell lymphoma Epstein-Barr Virus Infections - pathology Hematopoietic Stem Cell Transplantation Herpesvirus 4, Human Humans immunoglobulin gene rearrangements Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Neoplasm Recurrence, Local - pathology relapse second primary lymphoma Transplantation, Autologous
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Zusammenfassung:	Approximately one-third of patients with diffuse large B-cell lymphoma (DLBCL) relapse and often require salvage chemotherapy followed by autologous stem cell transplantation. In most cases, the clonal relationship between the first diagnosis and subsequent relapse is not assessed, thereby potentially missing the identification of second primary lymphoma. In this study, the clonal relationship of 59 paired DLBCL diagnoses and recurrences was established by next-generation sequencing–based detection of immunoglobulin gene rearrangements. Among 50 patients with interpretable results, 43 patients (86%) developed clonally related relapsed disease. This was observed in 100% of early recurrences (
ISSN:	0893-3952 1530-0285
DOI:	10.1016/j.modpat.2023.100119