Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer

In this trial, omission of radiotherapy after breast-conserving surgery led to an increased incidence of local recurrence but no difference in distant recurrence as the first event or breast cancer–specific or overall survival.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-02, Vol.388 (7), p.585-594
Hauptverfasser:	Kunkler, Ian H., Williams, Linda J., Jack, Wilma J.L., Cameron, David A., Dixon, J. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Breast - pathology Breast Cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Cancer surgery Confidence intervals Endocrine therapy Estrogens Female Hematology Humans Mammography Mastectomy, Segmental - adverse effects Neoplasm Recurrence, Local - mortality Neoplasm Staging Older people Oncology Patients Radiation therapy Radiotherapy, Adjuvant Software Statistical analysis Surgery Surgery General Survival Survival Analysis Treatments in Oncology Tumors Withholding Treatment Womens health
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Beschreibung
Zusammenfassung:	In this trial, omission of radiotherapy after breast-conserving surgery led to an increased incidence of local recurrence but no difference in distant recurrence as the first event or breast cancer–specific or overall survival.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2207586