Synthetic assembly of a series of glycopolymers having sialyl α2-3 lactose moieties connected with longer spacer arms

Synthetic assembly of a series of glycopolymers having sialyl α2-3 lactose moieties connected with longer spacer arms

[Display omitted] Glycopolymers having sialyl α2-3 lactose moieties via longer spacer arms were systematically prepared from the corresponding glycomonomers. Radical polymerization of glycomonomers gave a series of glycopolymers displaying various sugar densities. Fluorometric analyses of wheat germ...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2023-03, Vol.81, p.117209-117209, Article 117209
Hauptverfasser: Adachi, Ryota, Matsushita, Takahiko, Koyama, Tetsuo, Hatano, Ken, Matsuoka, Koji
Format: Artikel
Sprache:eng
Schlagworte:
Affinity constants
Carbohydrates
Fluorescence spectroscopy
Glycoclusters
Glycopolymers
Glycosides
Lactose
Lectins
Oligosaccharides
Polymers
Radical polymerizations
Sialic Acids
Sugars
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Zusammenfassung:[Display omitted] Glycopolymers having sialyl α2-3 lactose moieties via longer spacer arms were systematically prepared from the corresponding glycomonomers. Radical polymerization of glycomonomers gave a series of glycopolymers displaying various sugar densities. Fluorometric analyses of wheat germ agglutinin (WGA) against the glycopolymers were conducted and the results showed unique binding specificities on the basis of sugar densities.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2023.117209