STAT6 controls the stability and suppressive function of regulatory T cells

Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for the infiltration of inflammatory cells during the early stages of colitis‐associated cancer (CAC). In this study, we dissected the role of STAT6 i...

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Veröffentlicht in:	European journal of immunology 2023-05, Vol.53 (5), p.e2250128-n/a
Hauptverfasser:	Arroyo‐Olarte, Rubén D., Rivera‐Rugeles, Ana, Nava‐Lira, Eduardo, Sánchez‐Barrera, Ángel, Ledesma‐Soto, Yadira, Saavedra, Rafael, Armas‐López, Leonel, Terrazas, Luis I, Ávila‐Moreno, Federico, Leon‐Cabrera, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis CD25 antigen Colitis Colitis‐associated cancer Colorectal cancer Demethylation DNA methyltransferase DNMT1 protein Forkhead protein Forkhead Transcription Factors - metabolism Foxp3 Foxp3 protein Gene expression Immunoregulation Inflammation Interleukin 6 Latency Lymphocytes T Metastases Phenotypes Programmed Cell Death 1 Receptor - metabolism STAT6 Stat6 protein STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism T-Lymphocytes, Regulatory - metabolism Transforming Growth Factor beta - metabolism Tregs Tumorigenesis
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