Intravascular ultrasound provides additional insights in the hypertensive patients with focal renal artery fibromuscular dysplasia
To date, few study has defined the exact role or utility of intravascular ultrasound (IVUS) in the diagnosis and treatment of renal artery fibromuscular dysplasia (FMD). We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD....
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| Veröffentlicht in: | Hypertension research 2023-06, Vol.46 (6), p.1407-1416 |
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| creator | Kang, Yuanyuan Wu, Qihong Xu, Jianzhong Hong, Mona Ma, Yu Tang, Xiaofeng Zhu, Limin Gao, Pingjin Wang, Jiguang |
| description | To date, few study has defined the exact role or utility of intravascular ultrasound (IVUS) in the diagnosis and treatment of renal artery fibromuscular dysplasia (FMD). We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A prospective, observational study, including all patients with focal renal artery FMD admitted to the Ruijin hospital during 6 consecutive years (2015-2021). Based on IVUS imaging, focal FMD patients were classified as two subtypes: intima-media thickening (IMT) and negative remodeling (NR) of the whole vessel. A total of 36 consecutive patients (24 ± 7, 13-39 years) with focal renal artery FMD were enrolled. Angiographic unifocal type was present in 22 (61.1%) patients and tubular type was present in 14 (38.9%) patients. Among 22 patients with unifocal, IVUS showed that 18 (81.8%) had IMT and 4 (18.2%) had NR. 14 patients with tubular, IVUS showed 3 (21.4%) had IMT and 11 (78.6%) had NR. No difference in age of onset, gender, BMI, initial BP levels were found between IMT and NR subtypes. However, hypertension cure rates of short-term (48 h after angioplasty) (76.2% vs. 26.7%, p = 0.004) and long-term (1-6years) (90.5% vs. 20.0%, p |
| doi_str_mv | 10.1038/s41440-023-01216-y |
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We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A prospective, observational study, including all patients with focal renal artery FMD admitted to the Ruijin hospital during 6 consecutive years (2015-2021). Based on IVUS imaging, focal FMD patients were classified as two subtypes: intima-media thickening (IMT) and negative remodeling (NR) of the whole vessel. A total of 36 consecutive patients (24 ± 7, 13-39 years) with focal renal artery FMD were enrolled. Angiographic unifocal type was present in 22 (61.1%) patients and tubular type was present in 14 (38.9%) patients. Among 22 patients with unifocal, IVUS showed that 18 (81.8%) had IMT and 4 (18.2%) had NR. 14 patients with tubular, IVUS showed 3 (21.4%) had IMT and 11 (78.6%) had NR. No difference in age of onset, gender, BMI, initial BP levels were found between IMT and NR subtypes. However, hypertension cure rates of short-term (48 h after angioplasty) (76.2% vs. 26.7%, p = 0.004) and long-term (1-6years) (90.5% vs. 20.0%, p < 0.001) were higher in patients with IMT than in those with NR subtype. In present study, we described a new classification of focal renal artery FMD into IMT or NR subtype based on IVUS. Renal FMD Patients with IMT subtype were more likely to achieve cure of hypertension. We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A new classification of focal renal artery FMD into IMT or NR subtype based on IVUS was described. Renal FMD Patients with IMT subtype were more likely to achieve cure of hypertension.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-023-01216-y</identifier><identifier>PMID: 36765108</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Angioplasty ; Antihypertensives ; Catheters ; Fibromuscular Dysplasia - complications ; Fibromuscular Dysplasia - diagnostic imaging ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - diagnostic imaging ; Medical diagnosis ; Medical imaging ; Prospective Studies ; Renal Artery - diagnostic imaging ; Ultrasonic imaging ; Ultrasonography, Interventional ; Veins & arteries</subject><ispartof>Hypertension research, 2023-06, Vol.46 (6), p.1407-1416</ispartof><rights>2023. The Author(s), under exclusive licence to The Japanese Society of Hypertension.</rights><rights>The Author(s), under exclusive licence to The Japanese Society of Hypertension 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-351d4e937e8d885e0438824380162ecb814789886deb9e6010254d149c4597e03</citedby><cites>FETCH-LOGICAL-c331t-351d4e937e8d885e0438824380162ecb814789886deb9e6010254d149c4597e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36765108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Yuanyuan</creatorcontrib><creatorcontrib>Wu, Qihong</creatorcontrib><creatorcontrib>Xu, Jianzhong</creatorcontrib><creatorcontrib>Hong, Mona</creatorcontrib><creatorcontrib>Ma, Yu</creatorcontrib><creatorcontrib>Tang, Xiaofeng</creatorcontrib><creatorcontrib>Zhu, Limin</creatorcontrib><creatorcontrib>Gao, Pingjin</creatorcontrib><creatorcontrib>Wang, Jiguang</creatorcontrib><title>Intravascular ultrasound provides additional insights in the hypertensive patients with focal renal artery fibromuscular dysplasia</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>To date, few study has defined the exact role or utility of intravascular ultrasound (IVUS) in the diagnosis and treatment of renal artery fibromuscular dysplasia (FMD). We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A prospective, observational study, including all patients with focal renal artery FMD admitted to the Ruijin hospital during 6 consecutive years (2015-2021). Based on IVUS imaging, focal FMD patients were classified as two subtypes: intima-media thickening (IMT) and negative remodeling (NR) of the whole vessel. A total of 36 consecutive patients (24 ± 7, 13-39 years) with focal renal artery FMD were enrolled. Angiographic unifocal type was present in 22 (61.1%) patients and tubular type was present in 14 (38.9%) patients. Among 22 patients with unifocal, IVUS showed that 18 (81.8%) had IMT and 4 (18.2%) had NR. 14 patients with tubular, IVUS showed 3 (21.4%) had IMT and 11 (78.6%) had NR. No difference in age of onset, gender, BMI, initial BP levels were found between IMT and NR subtypes. However, hypertension cure rates of short-term (48 h after angioplasty) (76.2% vs. 26.7%, p = 0.004) and long-term (1-6years) (90.5% vs. 20.0%, p < 0.001) were higher in patients with IMT than in those with NR subtype. In present study, we described a new classification of focal renal artery FMD into IMT or NR subtype based on IVUS. Renal FMD Patients with IMT subtype were more likely to achieve cure of hypertension. We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A new classification of focal renal artery FMD into IMT or NR subtype based on IVUS was described. Renal FMD Patients with IMT subtype were more likely to achieve cure of hypertension.</description><subject>Angioplasty</subject><subject>Antihypertensives</subject><subject>Catheters</subject><subject>Fibromuscular Dysplasia - complications</subject><subject>Fibromuscular Dysplasia - diagnostic imaging</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - diagnostic imaging</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Prospective Studies</subject><subject>Renal Artery - diagnostic imaging</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography, Interventional</subject><subject>Veins & arteries</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkT1v2zAQhokiQe26_QMZAgJZuqjlkRRFjYGRtAYMdElmghbPNQ1ZUkjKgdb88tK106ELP47Pe8ThIeQG2DdgQn-PEqRkBeOiYMBBFdMHMgchdSE5yCsyZ3Uu1kqoGfkU454xrssaPpKZUJUqgek5eVt1Kdijjc3Y2kDHNt9iP3aODqE_eoeRWud88n1nW-q76H_vUswHmnZId9OAIWGuHpEONnns8uOrTzu67ZscCHiK2cyEiW79JvSH8fKVm-LQ2ujtZ3K9tW3EL5d9QZ4fH56WP4v1rx-r5f26aISAVIgSnMRaVKid1iUyKbTmeWGgODYbDbLStdbK4aZGxYDxUjqQdSPLukImFuTruW-e7GXEmMzBxwbb1nbYj9HwqioVV2UlMnr3H7rvx5BHyZTmHISSoDPFz1QT-hgDbs0Q_MGGyQAzJ0PmbMhkQ-avITPl0O2l9bg5oPsXeVci_gD0144s</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Kang, Yuanyuan</creator><creator>Wu, Qihong</creator><creator>Xu, Jianzhong</creator><creator>Hong, Mona</creator><creator>Ma, Yu</creator><creator>Tang, Xiaofeng</creator><creator>Zhu, Limin</creator><creator>Gao, Pingjin</creator><creator>Wang, Jiguang</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230601</creationdate><title>Intravascular ultrasound provides additional insights in the hypertensive patients with focal renal artery fibromuscular dysplasia</title><author>Kang, Yuanyuan ; 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We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A prospective, observational study, including all patients with focal renal artery FMD admitted to the Ruijin hospital during 6 consecutive years (2015-2021). Based on IVUS imaging, focal FMD patients were classified as two subtypes: intima-media thickening (IMT) and negative remodeling (NR) of the whole vessel. A total of 36 consecutive patients (24 ± 7, 13-39 years) with focal renal artery FMD were enrolled. Angiographic unifocal type was present in 22 (61.1%) patients and tubular type was present in 14 (38.9%) patients. Among 22 patients with unifocal, IVUS showed that 18 (81.8%) had IMT and 4 (18.2%) had NR. 14 patients with tubular, IVUS showed 3 (21.4%) had IMT and 11 (78.6%) had NR. No difference in age of onset, gender, BMI, initial BP levels were found between IMT and NR subtypes. However, hypertension cure rates of short-term (48 h after angioplasty) (76.2% vs. 26.7%, p = 0.004) and long-term (1-6years) (90.5% vs. 20.0%, p < 0.001) were higher in patients with IMT than in those with NR subtype. In present study, we described a new classification of focal renal artery FMD into IMT or NR subtype based on IVUS. Renal FMD Patients with IMT subtype were more likely to achieve cure of hypertension. We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A new classification of focal renal artery FMD into IMT or NR subtype based on IVUS was described. Renal FMD Patients with IMT subtype were more likely to achieve cure of hypertension.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>36765108</pmid><doi>10.1038/s41440-023-01216-y</doi><tpages>10</tpages></addata></record> |
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| subjects | Angioplasty Antihypertensives Catheters Fibromuscular Dysplasia - complications Fibromuscular Dysplasia - diagnostic imaging Humans Hypertension Hypertension - complications Hypertension - diagnostic imaging Medical diagnosis Medical imaging Prospective Studies Renal Artery - diagnostic imaging Ultrasonic imaging Ultrasonography, Interventional Veins & arteries |
| title | Intravascular ultrasound provides additional insights in the hypertensive patients with focal renal artery fibromuscular dysplasia |
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