Trial of Endovascular Thrombectomy for Large Ischemic Strokes
In a trial involving patients with large acute strokes, endovascular thrombectomy resulted in better functional outcomes than medical care alone but was associated with vascular complications.
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| Veröffentlicht in: | The New England journal of medicine 2023-04, Vol.388 (14), p.1259-1271 |
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| container_title | The New England journal of medicine |
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| creator | Sarraj, Amrou Hassan, Ameer E. Abraham, Michael G. Ortega-Gutierrez, Santiago Kasner, Scott E. Hussain, M. Shazam Chen, Michael Blackburn, Spiros Sitton, Clark W. Churilov, Leonid Sundararajan, Sophia Hu, Yin C. Herial, Nabeel A. Jabbour, Pascal Gibson, Daniel Wallace, Adam N. Arenillas, Juan F. Tsai, Jenny P. Budzik, Ronald F. Hicks, William J. Kozak, Osman Yan, Bernard Cordato, Dennis J. Manning, Nathan W. Parsons, Mark W. Hanel, Ricardo A. Aghaebrahim, Amin N. Wu, Teddy Y. Cardona-Portela, Pere Pérez de la Ossa, Natalia Schaafsma, Joanna D. Blasco, Jordi Sangha, Navdeep Warach, Steven Gandhi, Chirag D. Kleinig, Timothy J. Sahlein, Daniel Elijovich, Lucas Tekle, Wondwossen Samaniego, Edgar A. Maali, Laith Abdulrazzak, M. Ammar Psychogios, Marios N. Shuaib, Ashfaq Pujara, Deep K. Shaker, Faris Johns, Hannah Sharma, Gagan Yogendrakumar, Vignan Ng, Felix C. Rahbar, Mohammad H. Cai, Chunyan Lavori, Philip Hamilton, Scott Nguyen, Thanh Fifi, Johanna T. Davis, Stephen Wechsler, Lawrence Pereira, Vitor M. Lansberg, Maarten G. Hill, Michael D. Grotta, James C. Ribo, Marc Campbell, Bruce C. Albers, Gregory W. |
| description | In a trial involving patients with large acute strokes, endovascular thrombectomy resulted in better functional outcomes than medical care alone but was associated with vascular complications. |
| doi_str_mv | 10.1056/NEJMoa2214403 |
| format | Article |
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Shazam ; Chen, Michael ; Blackburn, Spiros ; Sitton, Clark W. ; Churilov, Leonid ; Sundararajan, Sophia ; Hu, Yin C. ; Herial, Nabeel A. ; Jabbour, Pascal ; Gibson, Daniel ; Wallace, Adam N. ; Arenillas, Juan F. ; Tsai, Jenny P. ; Budzik, Ronald F. ; Hicks, William J. ; Kozak, Osman ; Yan, Bernard ; Cordato, Dennis J. ; Manning, Nathan W. ; Parsons, Mark W. ; Hanel, Ricardo A. ; Aghaebrahim, Amin N. ; Wu, Teddy Y. ; Cardona-Portela, Pere ; Pérez de la Ossa, Natalia ; Schaafsma, Joanna D. ; Blasco, Jordi ; Sangha, Navdeep ; Warach, Steven ; Gandhi, Chirag D. ; Kleinig, Timothy J. ; Sahlein, Daniel ; Elijovich, Lucas ; Tekle, Wondwossen ; Samaniego, Edgar A. ; Maali, Laith ; Abdulrazzak, M. Ammar ; Psychogios, Marios N. ; Shuaib, Ashfaq ; Pujara, Deep K. ; Shaker, Faris ; Johns, Hannah ; Sharma, Gagan ; Yogendrakumar, Vignan ; Ng, Felix C. ; Rahbar, Mohammad H. ; Cai, Chunyan ; Lavori, Philip ; Hamilton, Scott ; Nguyen, Thanh ; Fifi, Johanna T. ; Davis, Stephen ; Wechsler, Lawrence ; Pereira, Vitor M. ; Lansberg, Maarten G. ; Hill, Michael D. ; Grotta, James C. ; Ribo, Marc ; Campbell, Bruce C. ; Albers, Gregory W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-c36575454baf3fe34b357df39eb1e2b2c39536d8c5ea56e49925cace45d334103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Brain Ischemia - diagnostic imaging</topic><topic>Brain Ischemia - drug therapy</topic><topic>Brain Ischemia - surgery</topic><topic>Cardiovascular system</topic><topic>Carotid arteries</topic><topic>Carotid artery</topic><topic>Carotid Artery Diseases - complications</topic><topic>Cerebral blood flow</topic><topic>Cerebral Hemorrhage - chemically induced</topic><topic>Cerebral Hemorrhage - etiology</topic><topic>Cerebral infarction</topic><topic>Clinical trials</topic><topic>Computed tomography</topic><topic>Edema</topic><topic>Emergency Medicine</topic><topic>Endovascular Procedures - adverse effects</topic><topic>Endovascular Procedures - methods</topic><topic>Fibrinolytic Agents - adverse effects</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Infarction, Middle Cerebral Artery - complications</topic><topic>Ischemia</topic><topic>Ischemic Stroke - diagnostic imaging</topic><topic>Ischemic Stroke - drug therapy</topic><topic>Ischemic Stroke - surgery</topic><topic>Magnetic resonance imaging</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Patient safety</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>Radiology General</topic><topic>Recovery of Function</topic><topic>Software</topic><topic>Stroke</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - drug therapy</topic><topic>Stroke - surgery</topic><topic>Thrombectomy - adverse effects</topic><topic>Thrombectomy - methods</topic><topic>Tomography</topic><topic>Treatment Outcome</topic><topic>Vasoconstriction</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarraj, Amrou</creatorcontrib><creatorcontrib>Hassan, Ameer E.</creatorcontrib><creatorcontrib>Abraham, Michael G.</creatorcontrib><creatorcontrib>Ortega-Gutierrez, Santiago</creatorcontrib><creatorcontrib>Kasner, Scott E.</creatorcontrib><creatorcontrib>Hussain, M. Shazam</creatorcontrib><creatorcontrib>Chen, Michael</creatorcontrib><creatorcontrib>Blackburn, Spiros</creatorcontrib><creatorcontrib>Sitton, Clark W.</creatorcontrib><creatorcontrib>Churilov, Leonid</creatorcontrib><creatorcontrib>Sundararajan, Sophia</creatorcontrib><creatorcontrib>Hu, Yin C.</creatorcontrib><creatorcontrib>Herial, Nabeel A.</creatorcontrib><creatorcontrib>Jabbour, Pascal</creatorcontrib><creatorcontrib>Gibson, Daniel</creatorcontrib><creatorcontrib>Wallace, Adam N.</creatorcontrib><creatorcontrib>Arenillas, Juan F.</creatorcontrib><creatorcontrib>Tsai, Jenny P.</creatorcontrib><creatorcontrib>Budzik, Ronald F.</creatorcontrib><creatorcontrib>Hicks, William J.</creatorcontrib><creatorcontrib>Kozak, Osman</creatorcontrib><creatorcontrib>Yan, Bernard</creatorcontrib><creatorcontrib>Cordato, Dennis J.</creatorcontrib><creatorcontrib>Manning, Nathan W.</creatorcontrib><creatorcontrib>Parsons, Mark W.</creatorcontrib><creatorcontrib>Hanel, Ricardo A.</creatorcontrib><creatorcontrib>Aghaebrahim, Amin N.</creatorcontrib><creatorcontrib>Wu, Teddy Y.</creatorcontrib><creatorcontrib>Cardona-Portela, Pere</creatorcontrib><creatorcontrib>Pérez de la Ossa, Natalia</creatorcontrib><creatorcontrib>Schaafsma, Joanna D.</creatorcontrib><creatorcontrib>Blasco, Jordi</creatorcontrib><creatorcontrib>Sangha, Navdeep</creatorcontrib><creatorcontrib>Warach, Steven</creatorcontrib><creatorcontrib>Gandhi, Chirag D.</creatorcontrib><creatorcontrib>Kleinig, Timothy J.</creatorcontrib><creatorcontrib>Sahlein, Daniel</creatorcontrib><creatorcontrib>Elijovich, Lucas</creatorcontrib><creatorcontrib>Tekle, Wondwossen</creatorcontrib><creatorcontrib>Samaniego, Edgar A.</creatorcontrib><creatorcontrib>Maali, Laith</creatorcontrib><creatorcontrib>Abdulrazzak, M. Ammar</creatorcontrib><creatorcontrib>Psychogios, Marios N.</creatorcontrib><creatorcontrib>Shuaib, Ashfaq</creatorcontrib><creatorcontrib>Pujara, Deep K.</creatorcontrib><creatorcontrib>Shaker, Faris</creatorcontrib><creatorcontrib>Johns, Hannah</creatorcontrib><creatorcontrib>Sharma, Gagan</creatorcontrib><creatorcontrib>Yogendrakumar, Vignan</creatorcontrib><creatorcontrib>Ng, Felix C.</creatorcontrib><creatorcontrib>Rahbar, Mohammad H.</creatorcontrib><creatorcontrib>Cai, Chunyan</creatorcontrib><creatorcontrib>Lavori, Philip</creatorcontrib><creatorcontrib>Hamilton, Scott</creatorcontrib><creatorcontrib>Nguyen, Thanh</creatorcontrib><creatorcontrib>Fifi, Johanna T.</creatorcontrib><creatorcontrib>Davis, Stephen</creatorcontrib><creatorcontrib>Wechsler, Lawrence</creatorcontrib><creatorcontrib>Pereira, Vitor M.</creatorcontrib><creatorcontrib>Lansberg, Maarten G.</creatorcontrib><creatorcontrib>Hill, Michael D.</creatorcontrib><creatorcontrib>Grotta, James C.</creatorcontrib><creatorcontrib>Ribo, Marc</creatorcontrib><creatorcontrib>Campbell, Bruce C.</creatorcontrib><creatorcontrib>Albers, Gregory W.</creatorcontrib><creatorcontrib>SELECT2 Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarraj, Amrou</au><au>Hassan, Ameer E.</au><au>Abraham, Michael G.</au><au>Ortega-Gutierrez, Santiago</au><au>Kasner, Scott E.</au><au>Hussain, M. 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Ammar</au><au>Psychogios, Marios N.</au><au>Shuaib, Ashfaq</au><au>Pujara, Deep K.</au><au>Shaker, Faris</au><au>Johns, Hannah</au><au>Sharma, Gagan</au><au>Yogendrakumar, Vignan</au><au>Ng, Felix C.</au><au>Rahbar, Mohammad H.</au><au>Cai, Chunyan</au><au>Lavori, Philip</au><au>Hamilton, Scott</au><au>Nguyen, Thanh</au><au>Fifi, Johanna T.</au><au>Davis, Stephen</au><au>Wechsler, Lawrence</au><au>Pereira, Vitor M.</au><au>Lansberg, Maarten G.</au><au>Hill, Michael D.</au><au>Grotta, James C.</au><au>Ribo, Marc</au><au>Campbell, Bruce C.</au><au>Albers, Gregory W.</au><aucorp>SELECT2 Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trial of Endovascular Thrombectomy for Large Ischemic Strokes</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2023-04-06</date><risdate>2023</risdate><volume>388</volume><issue>14</issue><spage>1259</spage><epage>1271</epage><pages>1259-1271</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>In a trial involving patients with large acute strokes, endovascular thrombectomy resulted in better functional outcomes than medical care alone but was associated with vascular complications.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>36762865</pmid><doi>10.1056/NEJMoa2214403</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2135-0504</orcidid><orcidid>https://orcid.org/0000-0003-4430-3276</orcidid><orcidid>https://orcid.org/0000-0002-6269-1543</orcidid><orcidid>https://orcid.org/0000-0002-2810-1685</orcidid><orcidid>https://orcid.org/0000-0003-3632-9433</orcidid><orcidid>https://orcid.org/0000-0003-1845-1769</orcidid><orcidid>https://orcid.org/0000-0003-4462-5232</orcidid><orcidid>https://orcid.org/0000-0002-3667-4248</orcidid><orcidid>https://orcid.org/0000-0002-9914-6311</orcidid><orcidid>https://orcid.org/0000-0003-0418-6917</orcidid><orcidid>https://orcid.org/0000-0001-6187-894X</orcidid><orcidid>https://orcid.org/0000-0001-9242-043X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2023-04, Vol.388 (14), p.1259-1271 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2775623716 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Brain Ischemia - diagnostic imaging Brain Ischemia - drug therapy Brain Ischemia - surgery Cardiovascular system Carotid arteries Carotid artery Carotid Artery Diseases - complications Cerebral blood flow Cerebral Hemorrhage - chemically induced Cerebral Hemorrhage - etiology Cerebral infarction Clinical trials Computed tomography Edema Emergency Medicine Endovascular Procedures - adverse effects Endovascular Procedures - methods Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use Hemorrhage Humans Infarction, Middle Cerebral Artery - complications Ischemia Ischemic Stroke - diagnostic imaging Ischemic Stroke - drug therapy Ischemic Stroke - surgery Magnetic resonance imaging Neurology Neurosurgery Patient safety Prospective Studies Radiology Radiology General Recovery of Function Software Stroke Stroke - diagnostic imaging Stroke - drug therapy Stroke - surgery Thrombectomy - adverse effects Thrombectomy - methods Tomography Treatment Outcome Vasoconstriction Veins & arteries |
| title | Trial of Endovascular Thrombectomy for Large Ischemic Strokes |
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