Chemogenetic Activation of Lateral Habenula Accelerates the Extinction of the Appetitive Conditioned Responses
A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditione...
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| Veröffentlicht in: | Behavioral neuroscience 2023-04, Vol.137 (2), p.95-100 |
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| creator | Kim, Dong-Hee Choi, Bo-Ryoung Jin, In-Beom Jeon, Jin-Ah Park, Sang-Pil Han, Jung-Soo |
| description | A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction. |
| doi_str_mv | 10.1037/bne0000553 |
| format | Article |
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Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/bne0000553</identifier><identifier>PMID: 36757972</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Animal ; Animals ; Appetite ; Brain ; Classical Conditioning ; Conditioned Responses ; Conditioned stimulus ; Conditioning, Classical - physiology ; Conditioning, Operant ; Extinction (Learning) ; Extinction behavior ; Extinction, Psychological - physiology ; Food ; Genetics ; Habenula ; Habenula - physiology ; Luteinizing hormone ; Male ; Rats ; Unconditioned stimulus</subject><ispartof>Behavioral neuroscience, 2023-04, Vol.137 (2), p.95-100</ispartof><rights>2023 American Psychological Association</rights><rights>2023, American Psychological Association</rights><rights>Copyright American Psychological Association Apr 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a379t-6c28da4d5269b07847a2e3bb0f3baf0d3b5b2653104a4bc83a10a7135289a4743</citedby><orcidid>0000-0001-8447-4518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36757972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schoenbaum, Geoffrey</contributor><creatorcontrib>Kim, Dong-Hee</creatorcontrib><creatorcontrib>Choi, Bo-Ryoung</creatorcontrib><creatorcontrib>Jin, In-Beom</creatorcontrib><creatorcontrib>Jeon, Jin-Ah</creatorcontrib><creatorcontrib>Park, Sang-Pil</creatorcontrib><creatorcontrib>Han, Jung-Soo</creatorcontrib><title>Chemogenetic Activation of Lateral Habenula Accelerates the Extinction of the Appetitive Conditioned Responses</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. 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The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction.</description><subject>Animal</subject><subject>Animals</subject><subject>Appetite</subject><subject>Brain</subject><subject>Classical Conditioning</subject><subject>Conditioned Responses</subject><subject>Conditioned stimulus</subject><subject>Conditioning, Classical - physiology</subject><subject>Conditioning, Operant</subject><subject>Extinction (Learning)</subject><subject>Extinction behavior</subject><subject>Extinction, Psychological - physiology</subject><subject>Food</subject><subject>Genetics</subject><subject>Habenula</subject><subject>Habenula - physiology</subject><subject>Luteinizing hormone</subject><subject>Male</subject><subject>Rats</subject><subject>Unconditioned stimulus</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1rFTEUBuAgir2tbvwBMuBGKqP5nGSWl0trCxcE0XU4mTljp8xNxiRT7L9vhtsquGg2gXMeXg68hLxj9DOjQn9xHml5SokXZMNa0daUGvmSbKgWqtZUyhNymtJtMZJK9ZqciEYr3Wq-IX53g4fwCz3msau2XR7vII_BV2Go9pAxwlRdgUO_TFDWHU5llDFV-Qariz959N0TXyfbeS5BJQSrXfD9uO6wr75jmoNPmN6QVwNMCd8-_mfk5-XFj91Vvf_29Xq33dcgdJvrpuOmB9kr3rSOaiM1cBTO0UE4GGgvnHK8UYJRCdJ1RgCjoJlQ3LQgtRRn5OMxd47h94Ip28OYyvETeAxLslxraVrTqJV--I_ehiX6cl1RxphWNA17XmnZcMmFKer8qLoYUoo42DmOB4j3llG7dmX_dVXw-8fIxR2w_0ufying0xHADHZO9x3EUtKEqVtiRJ_XMMtKKLetEg8QD52f</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Kim, Dong-Hee</creator><creator>Choi, Bo-Ryoung</creator><creator>Jin, In-Beom</creator><creator>Jeon, Jin-Ah</creator><creator>Park, Sang-Pil</creator><creator>Han, Jung-Soo</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8447-4518</orcidid></search><sort><creationdate>20230401</creationdate><title>Chemogenetic Activation of Lateral Habenula Accelerates the Extinction of the Appetitive Conditioned Responses</title><author>Kim, Dong-Hee ; Choi, Bo-Ryoung ; Jin, In-Beom ; Jeon, Jin-Ah ; Park, Sang-Pil ; Han, Jung-Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a379t-6c28da4d5269b07847a2e3bb0f3baf0d3b5b2653104a4bc83a10a7135289a4743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal</topic><topic>Animals</topic><topic>Appetite</topic><topic>Brain</topic><topic>Classical Conditioning</topic><topic>Conditioned Responses</topic><topic>Conditioned stimulus</topic><topic>Conditioning, Classical - physiology</topic><topic>Conditioning, Operant</topic><topic>Extinction (Learning)</topic><topic>Extinction behavior</topic><topic>Extinction, Psychological - physiology</topic><topic>Food</topic><topic>Genetics</topic><topic>Habenula</topic><topic>Habenula - physiology</topic><topic>Luteinizing hormone</topic><topic>Male</topic><topic>Rats</topic><topic>Unconditioned stimulus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dong-Hee</creatorcontrib><creatorcontrib>Choi, Bo-Ryoung</creatorcontrib><creatorcontrib>Jin, In-Beom</creatorcontrib><creatorcontrib>Jeon, Jin-Ah</creatorcontrib><creatorcontrib>Park, Sang-Pil</creatorcontrib><creatorcontrib>Han, Jung-Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dong-Hee</au><au>Choi, Bo-Ryoung</au><au>Jin, In-Beom</au><au>Jeon, Jin-Ah</au><au>Park, Sang-Pil</au><au>Han, Jung-Soo</au><au>Schoenbaum, Geoffrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemogenetic Activation of Lateral Habenula Accelerates the Extinction of the Appetitive Conditioned Responses</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>137</volume><issue>2</issue><spage>95</spage><epage>100</epage><pages>95-100</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><abstract>A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>36757972</pmid><doi>10.1037/bne0000553</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8447-4518</orcidid></addata></record> |
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| subjects | Animal Animals Appetite Brain Classical Conditioning Conditioned Responses Conditioned stimulus Conditioning, Classical - physiology Conditioning, Operant Extinction (Learning) Extinction behavior Extinction, Psychological - physiology Food Genetics Habenula Habenula - physiology Luteinizing hormone Male Rats Unconditioned stimulus |
| title | Chemogenetic Activation of Lateral Habenula Accelerates the Extinction of the Appetitive Conditioned Responses |
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