Chemogenetic Activation of Lateral Habenula Accelerates the Extinction of the Appetitive Conditioned Responses

A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditione...

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Veröffentlicht in:Behavioral neuroscience 2023-04, Vol.137 (2), p.95-100
Hauptverfasser: Kim, Dong-Hee, Choi, Bo-Ryoung, Jin, In-Beom, Jeon, Jin-Ah, Park, Sang-Pil, Han, Jung-Soo
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Sprache:eng
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Zusammenfassung:A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction.
ISSN:0735-7044
1939-0084
DOI:10.1037/bne0000553