Biocompatible dressing for pediatric hypospadias repair

Purpose The search for an ideal Hypospadias repair dressing continues. We aimed to develop a hypoallergenic optimized biocompatible dressing (BD). Method BD with a multi-layered structure of hydrophilic treated Polypropylene with three-layered technologies; Absorbent-spunlaced hydroentangled polyester/viscose blend, outer Polypropylene, Polyester, Acrylic, and Spandex, with super Absorbent Polymer and Acrylic adhesive. Wistar rat abdominal wound model was divided into two groups: control (normal gauze dressing with adhesive) and Study (BD). The physical properties and wound characteristics were compared. Results Average mass: thickness of BD was 626.7 ± 5.6 g m −2 : 2.6 ± 0.015 mm. Absorption was 1425.2 ± 127.6%. Percentage desorption of solution A from dressings at 24:40 h was 1249 ± 150%:1417 ± 230%. BD was hydrophilic with no particles/residue after immersion and pH neutral. The average air permeability was 11.6 ± 1.6 cm 3 /cm 2 /sec. The tensile force was 200N–220N with an extension on the breaking point at 24 mm. BD was superior for ease of removability on Day 6 ( p = 0.012) and sticking quality ( p = 0.036), absorption ( p = 0.036), ease of removability( p = 0.036), and sustenance ( p = 0.030) on Day 10. BD dressing demonstrated better wound healing ( p = 0.015) and decreased redness ( p = 0.002) on Day 10. Histopathological healing was better with BD on Day 14( p = 0.025) and Day 20 ( p = 0.034). Conclusion BD demonstrated better desirable physical and wound healing qualities with less inflammation compared with control normal dressing.