The importance of antimicrobial peptides (AMPs) in amphibian skin defense

Antimicrobial peptides (AMPs) are produced for defense in nearly all taxa from simple bacteria to complex mammalian species. Some amphibian families have developed this defensive strategy to a high level of sophistication by loading the AMPs into specialized granular glands within the dermis. Enervated by the sympathetic nervous system, the granular glands are poised to deliver an array of AMPs to cleanse the wound and facilitate healing. There have been a number of excellent review publications in recent years that describe amphibian AMPs with an emphasis on their possible uses for human medicine. Instead, my aim here is to review what is known about the nature of amphibian AMPs, the diversity of amphibian AMPs, regulation of their production, and to provide the accumulated evidence that they do, indeed, play an important role in the protection of amphibian skin, vital for survival. While much has been learned about amphibian AMPs, there are still important gaps in our understanding of peptide synthesis, storage, and functions. •Amphibian antimicrobial peptides (AMPs) are numerous and diverse.•Secreted AMPs protect amphibians against diverse skin pathogens.•AMPs are highly expressed in amphibian skin but can be found in other tissues.•Amphibian AMPs may serve as a protective skin mantle or to cleanse a wound.•Some amphibian AMPs have wound healing and immunomodulatory activity.