NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantly acquired at low-temperature. The constructed NIR luminogen...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2023-03, Vol.59 (19), p.2743-2746
Hauptverfasser: Yang, Xinzhe, Ding, Keke, Zhang, Guiquan, Han, Pengbo, Hu, Rong, Wang, Zhiming, Qin, Anjun, Tang, Ben Zhong
Format: Artikel
Sprache:eng
Schlagworte:
Ablation
Cell Line, Tumor
Down-Regulation
HSP90 Heat-Shock Proteins - metabolism
Humans
Hyperthermia, Induced
Low temperature
Near infrared radiation
Neoplasms
Phototherapy
Photothermal conversion
Photothermal Therapy
Temperature
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Beschreibung
Zusammenfassung:A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantly acquired at low-temperature. The constructed NIR luminogen efficiently triggered the down-regulation of the HSP90α protein through photo-thermal conversion based on a gene interference strategy both in vitro and in vivo .
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc06932f