Endoscopic Multiport Approach for Exenteration of the Infratemporal Fossa

Objective To demonstrate anatomic relationships pertinent to the endoscopic multiport approach to the infratemporal fossa (ITF). Discuss advantages and limitations of each individual approach. Study Design Cadaveric study. Methods Endoscopic and endoscopic‐assisted endonasal transpterygoid, sublabial transmaxillary, endoscopic transorbital, and endoscopic transoral approaches to accessing the ITF were completed in five silicone‐injected fresh cadaveric specimens (10 sides) with the assistance of 0, 30, and 450 rods‐lens endoscopes. Image guidance was used to confirm and document the anatomical relationships encountered in each approach. Results The endonasal endoscopic transpterygoid approach provides better visualization and more direct exposure to median structures. Endoscopic‐assisted sublabial transmaxillary approach enhances the field of exposure, angle of attack, and ease of instrumentation to the lateral part of the ITF. Endoscopic‐assisted transorbital approach via the inferior orbital fissure provided cephalic and anterior access. Endoscopic‐assisted transoral approach complements the access to lesions extending inferior to the hard palate or far lateral to the mandibular condyle. Conclusions A combination of minimal access infratemporal approaches can provide adequate exposure of the entire ITF while avoiding some of the morbidity associated with open approaches. Level of Evidence NA Laryngoscope, 133:1367–1374, 2023 New minimally endoscopic multiport approach to infratemporal fossa. Step‐by‐step cadaveric dissection.