Simultaneous determination of 10 first‐generation histamine h1 receptor blockers in feeds by ultra‐high‐performance liquid chromatography triple quadrupole ion trap hybrid mass spectrometer

A method for simultaneous determination of 10 first‐generation histamine H1 receptor blockers in feeds by ultra‐high‐performance liquid chromatography triple quadrupole mass spectrometry combined with solid phase extraction. Instrument conditions, extraction solvents, and purification methods have been optimized. Under the optimum conditions, these analytes were separated effectively at 6 min. These feeds have been extracted by acid acetonitrile and purified by mixed cation exchange solid‐phase extraction. The performance of this method meets the requirements of veterinary residue detection in feeds in China. It is appropriate for the confirmatory monitoring and quantitative analysis of 105 feed samples, five kinds of histamine H1 receptor blockers have been detected in 10 samples.