Translational Challenges in Psychedelic Medicine

Translational Challenges in Psychedelic Medicine

A “nonpsychedelic psychedelic” compound was shown to have anxiolytic and antidepressive effects in a mouse model. This commentary asks whether assumptions implicit in mouse modeling can be trusted to translate to humans.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2023-02, Vol.388 (5), p.476-477
1. Verfasser: Carhart-Harris, Robin L.
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Antidepressants
Behavior
Depression
Drug dosages
Genetics
Genetics General
Hallucinogens - therapeutic use
Humans
LSD
Lysergic acid diethylamide
Mental depression
Mental health
Neuroscience
Pharmaceutical industry
Psilocybin - therapeutic use
Psychedelic drugs
Psychiatry
Psychiatry General
Rodents
Translational Research, Biomedical
Validity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A “nonpsychedelic psychedelic” compound was shown to have anxiolytic and antidepressive effects in a mouse model. This commentary asks whether assumptions implicit in mouse modeling can be trusted to translate to humans.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMcibr2213109