Phenylephrine-Induced Contraction in Guinea Pig Thoracic Aorta Is Triggered by Stimulation of α1L-Adrenoceptors Functionally Coupled with Store-Operated Ca2+ Channels and Voltage-Dependent Ca2+ Channels

Phenylephrine-Induced Contraction in Guinea Pig Thoracic Aorta Is Triggered by Stimulation of α1L-Adrenoceptors Functionally Coupled with Store-Operated Ca2+ Channels and Voltage-Dependent Ca2+ Channels

We examined whether the α1L-adrenoceptor (AR), which shows low affinity (pA2 

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Veröffentlicht in:Biological & pharmaceutical bulletin 2023/02/01, Vol.46(2), pp.309-319
Hauptverfasser: Obara, Keisuke, Yoshioka, Kento, Regadera, Montserrat De Dios, Matsuyama, Yusuke, Yashiro, Ayano, Miyokawa, Mayumi, Iura, Rumi, Tanaka, Yoshio
Format: Artikel
Sprache:eng
Schlagworte:
Adrenergic receptors
Affinity
Antagonists
Aorta
Calcium (extracellular)
Calcium channels
Calcium channels (voltage-gated)
Calcium influx
Coronary vessels
Endothelium
guinea pig thoracic aorta
Intracellular signalling
mRNA
Orai1 protein
Phenylephrine
phenylephrine-induced contraction
Prazosin
receptor-operated Ca2+ channel (ROCC)
store-operated Ca2+ channel (SOCC)
Thorax
Verapamil
voltage-dependent Ca2+ channel (VDCC)
Yohimbine
α1L-adrenoceptor
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Zusammenfassung:We examined whether the α1L-adrenoceptor (AR), which shows low affinity (pA2 
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b22-00754