Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase‐1

Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase‐1

The front cover artwork is provided by Dr. Karabencheva‐Christova's group at Michigan Technological University. The images show the initially formed and the catalytically productive conformations of MMP‐1 complex with the Triple Helical Peptide (THP), the free energy profile connecting them as...

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Veröffentlicht in:Chemphyschem 2023-02, Vol.24 (3), p.e202200943-n/a
Hauptverfasser: Waheed, Sodiq O., Varghese, Ann, DiCastri, Isabella, Kaski, Brenden, LaRouche, Ciara, Fields, Gregg B., Karabencheva‐Christova, Tatyana G.
Format: Artikel
Sprache:eng
Schlagworte:
Free energy
Matrix metalloproteinases
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Zusammenfassung:The front cover artwork is provided by Dr. Karabencheva‐Christova's group at Michigan Technological University. The images show the initially formed and the catalytically productive conformations of MMP‐1 complex with the Triple Helical Peptide (THP), the free energy profile connecting them as well as the coordination geometry of the catalytic zinc (II). The background shows the collagen macromolecule. Read the full text of the Research Article at 10.1002/cphc.202200649.
ISSN:1439-4235
1439-7641
DOI:10.1002/cphc.202200943