Programmed-stimuli responsive carrier-free multidrug delivery system for highly efficient trimodal combination therapy

Programed responsive carrier-free multidrug delivery system (ICG, DOX and INFa1b) was produced successfully for trimodal combination therapy of immunotherapy, photothermal therapy, and chemotherapy with programmed response against the tumor acid microenvironment and near infrared light. [Display omitted] Programmed response, carrier-free, and multimodal therapy drug delivery systems (DDS) are promising solutions to multidirectional cytotoxic effects, inefficient antitumor, and severe side effects for cancer therapy. Here, three widely used clinical drugs, interferon α1b (IFNα1b), indocyanine green (ICG), and doxorubicin (DOX), were prepared into carrier-free DDS IFNα1b-ICG-DOX (IID) by a simple one-step method without additional any reagents. IID can achieve smart and programmed DDS by combining low pH and near-infrared (NIR) light stimuli-responsive controlled release. In pH = 7.4 environments, our IID is about 380 nm in size with negative charge rounded particles; while they enter into the acid environment (pH