Insights into methanotroph carbon flux pave the way for methane biocatalysis

Methanotrophic bacteria are used industrially as catalysts for the bioconversion of methane (CH4) to valuable products. A landmark study by Kalyuzhnaya et al. identified the primary metabolic route for CH4 flux to central metabolic intermediates and alternative fermentative products in an industrially promising methanotroph, leading to a systems-level understanding of methanotrophy.