Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats
Background/Purpose This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival. Methods Based on appropriate dose of EVR ...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2023-07, Vol.30 (7), p.882-892 |
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| container_title | Journal of hepato-biliary-pancreatic sciences |
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| creator | Hirata, Masaaki Yagi, Shintaro Ito, Takashi Masano, Yuki Miyachi, Yosuke Yao, Siyuan Sonoda, Mari Masuda, Satohiro Haga, Hironori Hatano, Etsuro |
| description | Background/Purpose
This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival.
Methods
Based on appropriate dose of EVR + reduced‐TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed.
Results
After partial LT in EVR + reduced‐TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard‐TAC) on day 3 (59.3% vs. 72.9%; p |
| doi_str_mv | 10.1002/jhbp.1310 |
| format | Article |
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This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival.
Methods
Based on appropriate dose of EVR + reduced‐TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed.
Results
After partial LT in EVR + reduced‐TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard‐TAC) on day 3 (59.3% vs. 72.9%; p < .001) and 14 (88.1% vs. 95.5%; p = .01). Survival was 75%, which was not as high as the value of 100% observed for standard‐TAC, because neither infection nor rejection could be prevented. By contrast, survival after whole LT was 100% as neither infection nor rejection occurred.
Conclusions
The very early introduction of EVR + reduced‐TAC after partial LT delayed liver regeneration, and made it difficult to manage the dose required to suppress both infection and rejection. On the other hand, EVR + reduced‐TAC could be introduced safely very early after whole LT.
In this experimental study, Hirata and colleagues report that the very early introduction of everolimus with reduced‐dose tacrolimus after partial liver transplantation in rats delayed liver regeneration compared with standard‐dose tacrolimus monotherapy, and made it difficult to manage the dose required for suppression of both infection and rejection.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.1310</identifier><identifier>PMID: 36707057</identifier><language>eng</language><publisher>Japan: Wiley Subscription Services, Inc</publisher><subject>immunosuppressive regimen ; Infections ; Inhibitor drugs ; Liver ; Liver transplants ; mTOR inhibitor ; partial liver graft ; postoperative complications ; rejection</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2023-07, Vol.30 (7), p.882-892</ispartof><rights>2023 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery.</rights><rights>2023 Japanese Society of Hepato-Biliary-Pancreatic Surgery.</rights><rights>Copyright © 2023 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4380-e38ef11192f6bc9c3e286027b659be8e1425615f6624fd7b297319feaff1f9a23</cites><orcidid>0000-0002-6770-5297 ; 0000-0003-4248-3568</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.1310$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.1310$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36707057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirata, Masaaki</creatorcontrib><creatorcontrib>Yagi, Shintaro</creatorcontrib><creatorcontrib>Ito, Takashi</creatorcontrib><creatorcontrib>Masano, Yuki</creatorcontrib><creatorcontrib>Miyachi, Yosuke</creatorcontrib><creatorcontrib>Yao, Siyuan</creatorcontrib><creatorcontrib>Sonoda, Mari</creatorcontrib><creatorcontrib>Masuda, Satohiro</creatorcontrib><creatorcontrib>Haga, Hironori</creatorcontrib><creatorcontrib>Hatano, Etsuro</creatorcontrib><title>Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background/Purpose
This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival.
Methods
Based on appropriate dose of EVR + reduced‐TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed.
Results
After partial LT in EVR + reduced‐TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard‐TAC) on day 3 (59.3% vs. 72.9%; p < .001) and 14 (88.1% vs. 95.5%; p = .01). Survival was 75%, which was not as high as the value of 100% observed for standard‐TAC, because neither infection nor rejection could be prevented. By contrast, survival after whole LT was 100% as neither infection nor rejection occurred.
Conclusions
The very early introduction of EVR + reduced‐TAC after partial LT delayed liver regeneration, and made it difficult to manage the dose required to suppress both infection and rejection. On the other hand, EVR + reduced‐TAC could be introduced safely very early after whole LT.
In this experimental study, Hirata and colleagues report that the very early introduction of everolimus with reduced‐dose tacrolimus after partial liver transplantation in rats delayed liver regeneration compared with standard‐dose tacrolimus monotherapy, and made it difficult to manage the dose required for suppression of both infection and rejection.</description><subject>immunosuppressive regimen</subject><subject>Infections</subject><subject>Inhibitor drugs</subject><subject>Liver</subject><subject>Liver transplants</subject><subject>mTOR inhibitor</subject><subject>partial liver graft</subject><subject>postoperative complications</subject><subject>rejection</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp10U1PAyEQBmBiNGqqB_-A2cSLHloZ2MJy1EZtjYke9EzY7aA0-1XY1fTfSz_0YCIXYHjyZsIQcgZ0BJSy68VH3o6AA90jx5CJbChUxvZ_zzI9IqchLGhcHLji9JAccSGppGN5TJazqjVFlzQ2-US_StD4cpW4uvPNvC8619TrJ4xvTemqPiSxULp4TTy-Y43ebIyxXSy1xnfOlDvQeVOHtjR1tzWuTqIOJ-TAmjLg6W4fkLf7u9fJdPj0_DCb3DwNi5RndIg8QwsAilmRF6rgyDJBmczFWOWYIaRsLGBshWCpncucKclBWTTWglWG8QG53Oa2vln2GDpduVBgGRvCpg-aSUlTKSGVkV78oYum93XsTrOMKwqcpRDV1VYVvgnBo9Wtd5XxKw1Ur0eh16PQ61FEe75L7PMK57_y5-MjuN6CL1fi6v8k_Ti9fdlEfgP5jpQX</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Hirata, Masaaki</creator><creator>Yagi, Shintaro</creator><creator>Ito, Takashi</creator><creator>Masano, Yuki</creator><creator>Miyachi, Yosuke</creator><creator>Yao, Siyuan</creator><creator>Sonoda, Mari</creator><creator>Masuda, Satohiro</creator><creator>Haga, Hironori</creator><creator>Hatano, Etsuro</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6770-5297</orcidid><orcidid>https://orcid.org/0000-0003-4248-3568</orcidid></search><sort><creationdate>202307</creationdate><title>Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats</title><author>Hirata, Masaaki ; Yagi, Shintaro ; Ito, Takashi ; Masano, Yuki ; Miyachi, Yosuke ; Yao, Siyuan ; Sonoda, Mari ; Masuda, Satohiro ; Haga, Hironori ; Hatano, Etsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4380-e38ef11192f6bc9c3e286027b659be8e1425615f6624fd7b297319feaff1f9a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>immunosuppressive regimen</topic><topic>Infections</topic><topic>Inhibitor drugs</topic><topic>Liver</topic><topic>Liver transplants</topic><topic>mTOR inhibitor</topic><topic>partial liver graft</topic><topic>postoperative complications</topic><topic>rejection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirata, Masaaki</creatorcontrib><creatorcontrib>Yagi, Shintaro</creatorcontrib><creatorcontrib>Ito, Takashi</creatorcontrib><creatorcontrib>Masano, Yuki</creatorcontrib><creatorcontrib>Miyachi, Yosuke</creatorcontrib><creatorcontrib>Yao, Siyuan</creatorcontrib><creatorcontrib>Sonoda, Mari</creatorcontrib><creatorcontrib>Masuda, Satohiro</creatorcontrib><creatorcontrib>Haga, Hironori</creatorcontrib><creatorcontrib>Hatano, Etsuro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirata, Masaaki</au><au>Yagi, Shintaro</au><au>Ito, Takashi</au><au>Masano, Yuki</au><au>Miyachi, Yosuke</au><au>Yao, Siyuan</au><au>Sonoda, Mari</au><au>Masuda, Satohiro</au><au>Haga, Hironori</au><au>Hatano, Etsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2023-07</date><risdate>2023</risdate><volume>30</volume><issue>7</issue><spage>882</spage><epage>892</epage><pages>882-892</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background/Purpose
This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival.
Methods
Based on appropriate dose of EVR + reduced‐TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed.
Results
After partial LT in EVR + reduced‐TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard‐TAC) on day 3 (59.3% vs. 72.9%; p < .001) and 14 (88.1% vs. 95.5%; p = .01). Survival was 75%, which was not as high as the value of 100% observed for standard‐TAC, because neither infection nor rejection could be prevented. By contrast, survival after whole LT was 100% as neither infection nor rejection occurred.
Conclusions
The very early introduction of EVR + reduced‐TAC after partial LT delayed liver regeneration, and made it difficult to manage the dose required to suppress both infection and rejection. On the other hand, EVR + reduced‐TAC could be introduced safely very early after whole LT.
In this experimental study, Hirata and colleagues report that the very early introduction of everolimus with reduced‐dose tacrolimus after partial liver transplantation in rats delayed liver regeneration compared with standard‐dose tacrolimus monotherapy, and made it difficult to manage the dose required for suppression of both infection and rejection.</abstract><cop>Japan</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36707057</pmid><doi>10.1002/jhbp.1310</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6770-5297</orcidid><orcidid>https://orcid.org/0000-0003-4248-3568</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | immunosuppressive regimen Infections Inhibitor drugs Liver Liver transplants mTOR inhibitor partial liver graft postoperative complications rejection |
| title | Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats |
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