Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats

Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats

Background/Purpose This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival. Methods Based on appropriate dose of EVR ...

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Veröffentlicht in:Journal of hepato-biliary-pancreatic sciences 2023-07, Vol.30 (7), p.882-892
Hauptverfasser: Hirata, Masaaki, Yagi, Shintaro, Ito, Takashi, Masano, Yuki, Miyachi, Yosuke, Yao, Siyuan, Sonoda, Mari, Masuda, Satohiro, Haga, Hironori, Hatano, Etsuro
Format: Artikel
Sprache:eng
Schlagworte:
immunosuppressive regimen
Infections
Inhibitor drugs
Liver
Liver transplants
mTOR inhibitor
partial liver graft
postoperative complications
rejection
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Beschreibung
Zusammenfassung:Background/Purpose This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival. Methods Based on appropriate dose of EVR + reduced‐TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed. Results After partial LT in EVR + reduced‐TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard‐TAC) on day 3 (59.3% vs. 72.9%; p 
ISSN:1868-6974
1868-6982
DOI:10.1002/jhbp.1310