Economic evaluation of fluoride varnish application in preschoolers: A systematic review

Background Fluoride varnish (FV) is a convenient way of professionally applying fluoride in preschoolers. However, its modest anticaries effect highlights the need for economic evaluations. Aim To assess economic evaluations reporting applications of FV to reduce caries incidence in preschoolers. Design We included full economic evaluations with preschool participants, in which the intervention was FV and the outcome was related to dentin caries. We searched in CENTRAL; MEDLINE via PubMed; WEB OF SCIENCE; EMBASE; SCOPUS; LILACS; BBO; and BVS Economia em saúde, OpenGrey, and EconoLit. Clinical trial registers, thesis and dissertations, and meeting s were hand searched, as well as 11 dental journals. Risk of bias in the included studies was assessed using the Philips' and Drummond's (full and simplified) tools. Results Titles and s of 2871 articles were evaluated, and 200 were read in full. Eight cost‐effectiveness studies were included: five modeling and three within‐trial evaluations. None of the studies gave sufficient information to allow a thorough assessment using the bias tools. We did not combine the results of the studies due to the great heterogeneity among them. Four studies reported that FV in preschool children was a cost‐effective measure, but in one of these studies, sealants and fluoride toothpaste were more cost‐effective measures than the varnish, and three studies used limited data that compromised the generalizability of their results. The other four studies showed a large increase in costs due to the application of varnish and/or low cost‐effectiveness. Conclusion We did not find convincing overall evidence that applying FV in preschoolers is an anticaries cost‐effective measure. The protocol of this systematic review is available at Open Science Framework (https://osf.io/xw5va/).